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Ethyl ferulate (Alias: Ferulic acid ethyl ester, Ethyl 4'-hydroxy-3'-methoxycinnamate, Ethyl 3-(4-hydroxy-3...)

Name: Ethyl ferulate
Brand: TargetMol
SKU: T2821
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T2821 Copy Product Info

Purity: 99.91%

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Ethyl ferulate (Ethyl 4'-hydroxy-3'-methoxycinnamate) is the alkyl ester derivative of ferulic acid which is a naturally occurring plant product with anti-oxidative, anti-inflammatory, neuroprotective, and antiproliferative activities.

Ethyl ferulate

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Catalog No. T2821

Alias Ferulic acid ethyl ester, Ethyl 4'-hydroxy-3'-methoxycinnamate, Ethyl 3-(4-hydroxy-3-methoxyphenyl)acrylate

Cas No. 4046-02-0

Pack Size	Price	USA Stock	Global Stock
500 mg	$30	In Stock	In Stock
1 g	$46	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$32	In Stock	In Stock

In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.91%

Appearance:Solid

Color:White

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COA HNMR GC LCMS

Product Introduction

Ethyl ferulate AI Summary

Ethyl ferulate exhibits a diverse range of bioactivities, showcasing its multifaceted potential as a therapeutic agent. It demonstrates moderate inhibitory activity against TPA-induced superoxide (O2-) generation and shows a protective effect on cell viability in human promyelocytic leukemia HL-60 cells. The compound has notable antioxidant properties, including DPPH radical scavenging activity with a Trolox equivalent antioxidant capacity of 0.593 at 50 µM, ABTS radical scavenging with a capacity of 2.538 Trolox equivalents at the same concentration, and the ability to inhibit hemolysis in human red blood cells induced by AAPH. In cancer research, Ethyl ferulate shows cytotoxic effects on various human cell lines, displaying different levels of potency. It exhibits an IC50 value of 2130 nM in HeLa cells, indicating its potential as an anti-cancer agent. Additionally, it inhibits the growth of MAOB with an IC50 value of 6700 nM and shows a Ki value of 385,000 nM for human recombinant His-tagged glyoxalase 1. The compound also possesses antimicrobial activity against Athelia rolfsii and Pythium sp., with inhibition rates of 43.0% and 50.0% respectively at 100 ppm. It displays anti-platelet activity by inhibiting ADP-induced platelet aggregation in rabbit platelet-rich plasma, with an IC50 of 193200 nM. In antiviral studies, Ethyl ferulate shows limited inhibition of HIV1 NL4-3 in human MT4 cells and weak inhibitory activity against HIV-1 associated RNase H and RNA-dependent DNA polymerase. Furthermore, it inhibits GSK3beta with a 21.38% inhibition rate and exhibits superoxide anion radical scavenging activity, contributing to its antioxidant profile. The compound has a log P value of 2.02, indicating moderate hydrophilicity. Overall, Ethyl ferulate presents a promising multi-target profile with activities spanning antioxidant, anticancer, antimicrobial, anti-platelet, and limited antiviral properties, making it a compound of interest for further therapeutic development..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Ethyl ferulate (Ethyl 4'-hydroxy-3'-methoxycinnamate) is the alkyl ester derivative of ferulic acid which is a naturally occurring plant product with anti-oxidative, anti-inflammatory, neuroprotective, and antiproliferative activities.
Synonyms	Ferulic acid ethyl ester, Ethyl 4'-hydroxy-3'-methoxycinnamate, Ethyl 3-(4-hydroxy-3-methoxyphenyl)acrylate

Chemical Properties

Molecular Weight	222.24
Formula	C₁₂H₁₄O₄
Cas No.	4046-02-0
Smiles	C(=CC(OCC)=O)C1=CC(OC)=C(O)C=C1
Relative Density.	1.0643 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (247.48 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4996 mL	22.4982 mL	44.9964 mL	224.9820 mL
5 mM	0.8999 mL	4.4996 mL	8.9993 mL	44.9964 mL
10 mM	0.4500 mL	2.2498 mL	4.4996 mL	22.4982 mL
20 mM	0.2250 mL	1.1249 mL	2.2498 mL	11.2491 mL
50 mM	0.0900 mL	0.4500 mL	0.8999 mL	4.4996 mL
100 mM	0.0450 mL	0.2250 mL	0.4500 mL	2.2498 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc