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TargetMol | Compound Library

ReFRAME Related Library

Catalog No. L9230

In 2018 Jeff Janes and his team constructed and published the ReFRAME library through data mining and literature research in the Proceedings of the National Academy of Sciences (PNAS). The team explained the application and utility of the ReFRAME library, where most of the compounds in the library have passed clinical trials Phase I with demonstrated safety profiles, which will significantly shorten the time to of drug candidates to enter clinical trials, reduce the risk of failure, and can be efficiently applied to early-stage drug development screening and discovery of lead compounds. The authors share the ReFRAME library on the Open Data Portal (https://reframedb.org ) with the aim of facilitating data sharing and drug discovery opportunities. The Global Center for Health Drug Development (GHDDI), founded by the Gates Foundation and Tsinghua University, has also applied the ReFRAME library to anti-COVID-19 drug discovery. TargetMol has compiled a library of 4080 ReFRAME compounds, which is a useful tool for drug repurposing and anti-COVID-19 drug development.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L9230

ReFRAME Related Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • A unique collection of 4080 compounds for high-throughput screening and high-content screening, an effective tool for drug repurposing and anti-COVID-19 drug development
  • Some compounds have been marketed and approved by FDA, EMA, NMPA and other authorities, and most have passed Phase I clinical studies
  • ReFRAME Related Library has excellent structural diversity through cluster analysis of structural diversity, including 2698 clusters (similarity between different clusters <70%), with an average of 1.2 compounds per cluster.
  • Covering multiple research areas: oncology, cardiovascular drugs, anti-inflammatory/immune, neurological drugs, respiratory drugs, etc.
  • Diverse targets, including 5-HT Receptor, Sodium Channel, p38 MAPK, PI3K, MEK, etc.
  • Detailed specifications, compound structure, target information, disease indication information, activity description, etc.
  • NMR, HPLC/LCMS and other detection techniques to ensure correct structure and high purity of the product and reduce false positives.

Packaging And Storage | TargetMol Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice

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Library Customization | TargetMol Library Composition

Autophagy
Apoptosis
Antibacterial
Antibiotic
Endogenous Metabolite
5-HT Receptor
COX
Adrenergic Receptor
Dopamine Receptor
Parasite
AChR
HIV Protease
Antifungal
Histamine Receptor
DNA/RNA Synthesis
Calcium Channel
PDE
Potassium Channel
Sodium Channel
VEGFR
PI3K
GABA Receptor
PPAR
Topoisomerase
Cytochromes P450
Glucocorticoid Receptor
HCV Protease
Dehydrogenase
Estrogen/progestogen Receptor
Prostaglandin Receptor
Reactive Oxygen Species
EGFR
Influenza Virus
Microtubule Associated
FLT
RAAS
SARS-CoV
Adenosine Receptor
NF-κB
CDK
Ferroptosis
JAK
Estrogen Receptor/ERR
FGFR
PDGFR
HDAC
c-Met/HGFR
Mitophagy
mTOR
Nucleoside Antimetabolite/Analog
Src
GPR
p38 MAPK
Androgen Receptor
c-Kit
MAO
iGluR
Reverse Transcriptase
GluR
HBV
HSV
TRP/TRPV Channel
Opioid Receptor
Virus Protease
Antioxidant
Progesterone Receptor
TNF
ATPase
PKC
Proteasome
Akt
Aurora Kinase
Bcr-Abl
Carbonic Anhydrase
HSP
NMDAR
ROS
Antiviral
Lipoxygenase
MEK
Raf
Tyrosine Kinases
Cholinesterase (ChE)
IL Receptor
Serotonin Transporter
AMPK
Antifection
Phosphatase
Retinoid Receptor
ALK
Endothelin Receptor
Integrin
MMP
Norepinephrine
P-gp
Reductase
STAT
Beta Amyloid
Cannabinoid Receptor
CXCR
DPP-4
Epigenetic Reader Domain
HER
LPL Receptor
Phospholipase
ribosome
TLR
Transferase
Caspase
CCR
c-RET
DNA Alkylator/Crosslinker
E1/E2/E3 Enzyme
HIF/HIF Prolyl-Hydroxylase
Histone Methyltransferase
Mitochondrial Metabolism
Monoamine Oxidase
PARP
S1P Receptor
Thrombin
Acyltransferase
Drug Metabolite
Proton pump
SGLT
Thyroid hormone receptor(THR)
Bcl-2 Family
Cysteine Protease
DNA Alkylation
DNA-PK
ERK
Gamma-secretase
Neurokinin receptor
NO Synthase
Nrf2
Syk
TGF-beta/Smad
DHFR
Hedgehog/Smoothened
Interleukin
PKA
Trk receptor
Tyrosinase
Aromatase
CaMK
CFTR
FXR
GSK-3
Guanylate cyclase
HMG-CoA Reductase
Hydroxylase
MRP
p53
PLK
ROCK
Sigma receptor
Vasopressin Receptor
Xanthine Oxidase
Amino Acids and Derivatives
Cholecystokinin Receptor
HIF
IGF-1R
Leukotriene Receptor
RSV
TAM Receptor
Wnt/beta-catenin
ADC Cytotoxin
Antifolate
ATM/ATR
CETP
c-Fms
Chloride channel
FAK
Glutathione Peroxidase
IκB/IKK
LTR
NADPH
OX Receptor
Ras
Serine Protease
Smo
Chk
FAAH
Factor Xa
Glucokinase
IAP
Indoleamine 2,3-Dioxygenase (IDO)
NOS
Platelet aggregation
ABC Transporter
Beta-Secretase
Casein Kinase
JNK
Ligand for E3 Ligase
LPA Receptor
Mdm2
P2X Receptor
P2Y Receptor
Serine/threonin kinase
Aminopeptidase
Annexin A
Aryl Hydrocarbon Receptor
BACE
CaSR
CSF-1R
DNA gyrase
Glucosidase
IDO
Immunology/Inflammation related
Melatonin Receptor
Monoamine Transporter
MT Receptor
NOD
PAK
PGE Synthase
Rho
ROS Kinase
S6 Kinase
Tie-2
BTK
Acetyl-CoA Carboxylase
Adenosine Deaminase
AhR
Anti-infection
DNA
DNA Methyltransferase
Ephrin Receptor
Fatty Acid Synthase
GHSR
IFNAR
Imidazoline Receptor
Molecular Glues
NOD-like Receptor (NLR)
OAT
PAI-1
PDK
ROR
Sirtuin
UGT
Angiotensin-converting Enzyme (ACE)
Arginase
BCRP
Bradykinin Receptor
Complement System
CRFR
CRM1
Decarboxylase
Epoxide Hydrolase
Gap Junction Protein
Glucagon Receptor
GlyT
GNRH Receptor
HCN Channel
Hexokinase
IRE1
Isocitrate Dehydrogenase (IDH)
Kinesin
Monocarboxylate transporter
Myosin
Na+/Ca2+ Exchanger
NAMPT
Neprilysin
Oxytocin Receptor
PAFR
Pim
Protease-activated Receptor
STING
transporter
Vitamin
Adenylyl Cyclase
Advanced Glycation End Products
ATP Citrate Lyase
cAMP
CGRP Receptor
c-Myc
CRISPR/Cas9
Discoidin Domain Receptor (DDR)
DprE1
DUB
FLAP
Free radical scavengers
Galectin
GluCls
Glutaminase
Glutathione reductase
gp120/CD4
GPCR19
Histone Demethylase
KSP
Ligands for Target Protein for PROTAC
Lipid
Liver X Receptor
MAPK
Melanocortin Receptor
MicroRNA
NADPH-oxidase
Na-K-Cl cotransporter
Neuropeptide Y Receptor
Porcupine
RIP kinase
SGK
Somatostatin
Stearoyl-CoA Desaturase (SCD)
Telomerase
Thrombopoietin Receptor
Wee1
Kras
ACK1
Anion Exchanger
ASK
Cell Cycle Arrest
Cell wall
GPX
GSNOR
GST
Hck
Histone Acetyltransferase
Hydrogenase
IRAK
KLF
LDL
Lipase
LRRK2
Lysosomal Autophagy
MALT
Melanin-concentrating Hormone Receptor (MCHR)
Methionine Adenosyltransferase (MAT)
MNK
Mucin
N-Acetylglucosaminyltransferase
NEDD8
Neurotensin Receptor
NPC1L1
p97
PAD
PD-1/PD-L1
PERK
Phosphorylase
PI4K
PKM
Procollagen C Proteinase
Prolyl Endopeptidase (PREP)
PROTACs
Protease
PYK2
Pyroptosis
RANKL/RANK
RAR/RXR
Survivin
Taste receptor
Thioredoxin
TOPK
VDA
VDAC
YAP

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