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GTPase

GTPases are a large family of hydrolase enzymes that bind to the nucleotide guanosine triphosphate (GTP) and hydrolyze it to guanosine diphosphate (GDP).

  • CID-4785700
    T71740852935-07-0In house
    CID-4785700 is a potent pan-GTPase inhibitor that inhibits Rab7 and inhibits the fungal histone acetyltransferase Rtt109 that binds to Asf1 and Vps75, and can be used in the study of lupus.
    • $350
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  • Exo-1
    T9200461681-88-9
    Exo-1 (Methyl 3-(4-fluorobenzoyl)-6-methyl-2-pyridinecarboxylate) is a synthetic compound that has been shown to affect the metabolism of various nutrients, as well as the regulation of various hormones. It has also been shown to have anti-inflammatory and anti-tumor effects.
    • $50
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    TargetMol | Citations Cited
  • Tyrphostin 8
    T349733785-90-8
    Tyrphostin 8(4-Hydroxybenzylidenemalononitrile) is a potent GTPase inhibitor that inhibits EGFR kinase with an IC50 of 560 μM.Tyrphostin 8 inhibits protein serine threonine calmodulin phosphatases (IC50=21 μM), enhances transferrin receptor-mediated transcytosis in Caco-2 cells, and increases the hypoglycemic effect of oral insulin-transferrin. hypoglycemic effect.
    • $31
    In Stock
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  • Dynamin inhibitory peptide Acetate
    T21798L
    Dynamin inhibitory peptide Acetate is a peptide with the sequence Gln-Val-Pro-Ser-Arg-Pro-Asn-Arg-Ala-Pro that inhibit the GTPase dynamin.
    • $117
    In Stock
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  • IMM-01
    T25529218795-74-5
    IMM-01 is a novel class of small-molecule agonists of the mammalian Diaphanous (mDia)-related formins, which act downstream of Rho GTPases to assemble actin filaments, and their organization with microfilaments to establish and maintain cell polarity during migration and asymmetric division. GTP-bound Rho activates mDia family members by disrupting the interaction between the DID and DAD autoregulatory domains, which releases the FH2 domain to modulate actin and microtubule dynamics[1].
    • $81
    In Stock
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  • Anti-inflammatory agent 49
    T83057851471-44-8In house
    Anti-inflammatory agent 49 is a potent inhibitor of Drp1-Fis1 interaction, inhibits GTPase, and can be used in the study of diseases caused by mitochondrial dysfunction.
    • $88
    In Stock
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  • RBC8
    T6634361185-42-4
    RBC8 is a specific GTPases RalA/RalB inhibitor by inhibiting the binding of Ral to its effector RALBP1, no inhibition on the GTPases RhoA and Ras.
    • $45
    In Stock
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    TargetMol | Citations Cited
  • QS11
    T4022944328-88-5
    QS11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. Modulates ARF-GTP levels and synergizes with the Wnt/β-catenin signaling pathway to upregulate β-catenin nuclear translocation. Also reduces in vitro migration of metastatic human breast cancer cells.
    • $37
    In Stock
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    TargetMol | Citations Cited
  • Gancaonin I
    TN4098126716-36-7
    Gancaonin I exhibits anti-BsFtsZ GTPase activities; it also shows significant inhibitory activity against B. subtilis, with a MIC value of 5 uM.
    • $1,998
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    TargetMol | Inhibitor Sale
  • NAV-2729
    T5142419547-11-8
    NAV-2729 inhibits six ArfGEFs (human ARNO, EFA6, BIG1, and BRAG2 and Legionella and Rickettsia RalF), the strongest effects being against BRAG2, Arf1 and Arf6.
    • $38
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  • Compound C108
    T3838715533-09-2
    Compound C108 is an inhibitor of GTPase-activating protein SH3 domain-binding protein 2 (G3BP2). Compound C108 can be used in studies about breast tumors and esophageal squamous cell carcinoma.
    • $38
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  • CCG-50014
    T6434883050-24-6
    CCG-50014 is a potent and selective inhibitor of RGS4 with IC50 of 30 nM.
    • $30
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  • CCG-63802
    T14897620112-78-9
    CCG-63802 is a reversible inhibitor of the regulator of G-protein signaling (RGS) protein and has the greatest potency at RGS4.
    • $36
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  • BQU57
    T22671637739-82-2
    BQU57 shows selective inhibition for Ral relative to Ras or Rho and inhibit xenograft tumor growth.
    • $38
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  • CCG-63808
    T14898620113-73-7
    CCG-63808 is a reversible inhibitor of regulator of G-protein signaling (RGS) proteins. CCG-63808 dose-dependently inhibits the TR-FRET signal between RGS4-AF488 and Tb-Gαo with IC50 values of 1.9 μM.
    • $43
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  • CCG 203769
    T10705410074-60-1
    CCG 203769 (Thiadiazolidinone (TDZD) deriv. 6) is a selective inhibitor of RGS4 with an IC50 of 17 nM for the RGS4-Gαo protein-protein interaction.
    • $81
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  • RBC10
    T24706362503-73-9
    RBC10 inhibits the binding of Ral to its effector RALBP1, as well as inhibiting Ral-mediated cell spreading of murine embryonic fibroblasts and anchorage-independent growth of human cancer cell lines.
    • $51
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  • ML-097
    T21970743456-83-9
    ML-097 (CID-2160985) is a pan activator of Ras-related GTPases
    • $59
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