store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SOS1-IN-15 is an orally active and potent SOS1 inhibitor with potential antitumor activity.SOS1-IN-15 is used in the study of colon cancer.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 148.00 | |
5 mg | In stock | $ 372.00 | |
10 mg | In stock | $ 662.00 | |
25 mg | In stock | $ 1,360.00 |
Description | SOS1-IN-15 is an orally active and potent SOS1 inhibitor with potential antitumor activity.SOS1-IN-15 is used in the study of colon cancer. |
Targets&IC50 | KRAS-SOS1:5 nM |
In vitro | In Mia-paca-2 pancreatic cancer cells, SOS1-IN-15 (0.1 nM-0.1 mM; 72 hours) inhibited cell proliferation with an IC50 of 178 ± 42 nM[1]. |
In vivo | In BALB/c nude mice bearing Mia-paca-2 pancreatic tumors, SOS1-IN-15 (50 mg/kg; oral administration, daily for 22 days) showed 49% tumor inhibition. No animal mortality and significant difference in the mice’s body weight were observed during the study period[1]. |
Molecular Weight | 536.548 |
Formula | C28H27F3N6O2 |
CAS No. | 2793404-47-2 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 2 mg/mL (3.73 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
SOS1-IN-15 2793404-47-2 MAPK Raf inhibitor inhibit