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Lu AE51090
🥰Excellent
Catalog No. T32913Cas No. 1186229-95-7
Alias LuAE-51090, LuAE51090, Lu AE-51090
Lu AE51090 is a highly selective agonist of the muscarinic M1 receptor, displaying minimal off-target activity across other muscarinic subtypes and a broad panel of G-protein-coupled receptors, ion channels, transporters, and enzymes, making Lu AE51090 a valuable pharmacological tool for studying muscarinic receptor function and selective receptor modulation.
Lu AE51090
🥰Excellent
Purity: 99.57%
Catalog No. T32913Alias LuAE-51090, LuAE51090, Lu AE-51090Cas No. 1186229-95-7
Lu AE51090 is a highly selective agonist of the muscarinic M1 receptor, displaying minimal off-target activity across other muscarinic subtypes and a broad panel of G-protein-coupled receptors, ion channels, transporters, and enzymes, making Lu AE51090 a valuable pharmacological tool for studying muscarinic receptor function and selective receptor modulation.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $293 | - | In Stock | |
| 5 mg | $722 | - | In Stock | |
| 10 mg | $987 | - | In Stock | |
| 25 mg | $1,520 | - | In Stock | |
| 50 mg | $1,980 | - | In Stock | |
| 100 mg | $2,760 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.57%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Lu AE51090 is a highly selective agonist of the muscarinic M1 receptor, displaying minimal off-target activity across other muscarinic subtypes and a broad panel of G-protein-coupled receptors, ion channels, transporters, and enzymes, making Lu AE51090 a valuable pharmacological tool for studying muscarinic receptor function and selective receptor modulation. |
| Targets&IC50 | M5 mAChR:8900 nM (Ki), M1 mAChR:61 nM (EC50), M3 mAChR:7000 nM (Ki), M4 mAChR:6900 nM (Ki), M2 mAChR:2200 nM (Ki) |
| In vitro | In the Ca2+ mobilization assay conducted using CHO-K1/BHK-21 cells expressing the corresponding receptor, Lu AE51090 (at concentrations up to 10 μM) exhibited agonist activity at the homo sapiens M1 receptor, with an EC₅₀ value of 61 nM and an Eₘₐₓ value of 83%[1]. |
| In vivo | A single subcutaneous injection of Lu AE51090 (0.31-20 mg/kg) was administered to male C57Bl/6J mice 30 minutes before the experiment. Lu AE51090 exerted pro-cognitive effects in a dose-dependent manner [1]. |
| Synonyms | LuAE-51090, LuAE51090, Lu AE-51090 |
| Molecular Weight | 407.51 |
| Formula | C24H29N3O3 |
| Cas No. | 1186229-95-7 |
| Smiles | O=C(NC1CCN(CCCN2C(=O)COC=3C=CC=CC32)CC1)CC=4C=CC=CC4 |
| Relative Density. | no data available |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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