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Lu AE51090
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Catalog No. T32913Cas No. 1186229-95-7
Alias LuAE-51090, LuAE51090, Lu AE-51090
Lu AE51090 is a highly selective agonist of the muscarinic M1 receptor, displaying minimal off-target activity across other muscarinic subtypes and a broad panel of G-protein-coupled receptors, ion channels, transporters, and enzymes, making Lu AE51090 a valuable pharmacological tool for studying muscarinic receptor function and selective receptor modulation.
Lu AE51090
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Purity: 99.57%
Catalog No. T32913Alias LuAE-51090, LuAE51090, Lu AE-51090Cas No. 1186229-95-7
Lu AE51090 is a highly selective agonist of the muscarinic M1 receptor, displaying minimal off-target activity across other muscarinic subtypes and a broad panel of G-protein-coupled receptors, ion channels, transporters, and enzymes, making Lu AE51090 a valuable pharmacological tool for studying muscarinic receptor function and selective receptor modulation.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $79 | - | In Stock | |
| 5 mg | $193 | - | In Stock | |
| 10 mg | $313 | - | In Stock | |
| 25 mg | $595 | - | In Stock | |
| 50 mg | $953 | - | In Stock | |
| 100 mg | $1,490 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.57%
Appearance:Solid
Color:White
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | Lu AE51090 is a highly selective agonist of the muscarinic M1 receptor, displaying minimal off-target activity across other muscarinic subtypes and a broad panel of G-protein-coupled receptors, ion channels, transporters, and enzymes, making Lu AE51090 a valuable pharmacological tool for studying muscarinic receptor function and selective receptor modulation. |
| Targets&IC50 | M1 mAChR:61 nM (EC50), M5 mAChR:8900 nM (Ki), M3 mAChR:7000 nM (Ki), M4 mAChR:6900 nM (Ki), M2 mAChR:2200 nM (Ki) |
| In vitro | In the Ca2+ mobilization assay conducted using CHO-K1/BHK-21 cells expressing the corresponding receptor, Lu AE51090 (at concentrations up to 10 μM) exhibited agonist activity at the homo sapiens M1 receptor, with an EC₅₀ value of 61 nM and an Eₘₐₓ value of 83%[1]. |
| In vivo | A single subcutaneous injection of Lu AE51090 (0.31-20 mg/kg) was administered to male C57Bl/6J mice 30 minutes before the experiment. Lu AE51090 exerted pro-cognitive effects in a dose-dependent manner [1]. |
| Synonyms | LuAE-51090, LuAE51090, Lu AE-51090 |
| Molecular Weight | 407.51 |
| Formula | C24H29N3O3 |
| Cas No. | 1186229-95-7 |
| Smiles | O=C(NC1CCN(CCCN2C(=O)COC=3C=CC=CC32)CC1)CC=4C=CC=CC4 |
| Relative Density. | no data available |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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