Powder: -20°C for 3 years | In solvent: -80°C for 1 year
2-deoxy-D-Glucose-13C6is intended for use as an internal standard for the quantification of 2-deoxy-D-glucose by GC- or LC-MS. 2-deoxy-D-Glucose is a glucose antimetabolite and an inhibitor of glycolysis.1,2It inhibits hexokinase, the enzyme that converts glucose to glucose-6-phosphate, as well as phosphoglucose isomerase, the enzyme that converts glucose-6-phosphate to fructose-6-phosphate.32-deoxy-D-Glucose (16 mM) induces apoptosis in SK-BR-3 cells, as well as inhibits the growth of 143B osteosarcoma cells cultured under hypoxic conditions when used at a concentration of 2 mg/ml.4,5
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | Inquiry | $ 88.00 | |
5 mg | Inquiry | $ 412.00 | |
10 mg | Inquiry | $ 735.00 |
Description | 2-deoxy-D-Glucose-13C6is intended for use as an internal standard for the quantification of 2-deoxy-D-glucose by GC- or LC-MS. 2-deoxy-D-Glucose is a glucose antimetabolite and an inhibitor of glycolysis.1,2It inhibits hexokinase, the enzyme that converts glucose to glucose-6-phosphate, as well as phosphoglucose isomerase, the enzyme that converts glucose-6-phosphate to fructose-6-phosphate.32-deoxy-D-Glucose (16 mM) induces apoptosis in SK-BR-3 cells, as well as inhibits the growth of 143B osteosarcoma cells cultured under hypoxic conditions when used at a concentration of 2 mg/ml.4,5 |
In vivo | In vivo, 2-deoxy-D-glucose (500 mg/kg) reduces tumor growth in 143B osteosarcoma and MV522 non-small cell lung cancer mouse xenograft models when used alone or in combination with doxorubicin or paclitaxel .6 |
Synonyms | 2-deoxy-D-Glucose-13C6 |
Molecular Weight | 165.15 |
Formula | C5C(13)H12O5 |
CAS No. | 201612-55-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: Soluble
DMSO: Soluble
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2-deoxy-D-Glucose-13C6 201612-55-7 2 deoxy D Glucose 13C6 2-deoxy-D-Glucose-13C-6 2deoxyDGlucose13C6 inhibitor inhibit