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Anti-SERPINE1 Antibody
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Catalog No. T9901A-1318 Copy Product Info
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Anti-SERPINE1 Antibody is a humanized monoclonal antibody targeting Serpin Family E Member 1 (SERPINE1/PAI-1). SERPINE1, also known as Plasminogen Activator Inhibitor-1 (PAI-1), is the primary physiological inhibitor of tissue-type (tPA) and urokinase-type (uPA) plasminogen activators, playing a critical role in regulating fibrinolysis, cell migration, and tissue remodeling. Elevated PAI-1 levels are associated with thrombosis, fibrosis, metabolic syndrome, and tumor progression (including immune evasion and metastasis). Anti-SERPINE1 Antibody specifically binds to PAI-1, neutralizing its inhibitory activity and restoring tPA/uPA-mediated plasmin generation to promote fibrinolysis and reduce extracellular matrix deposition. Additionally, the antibody blocks PAI-1-mediated upregulation of PD-L1, thereby enhancing anti-tumor immune responses in the tumor microenvironment, and possesses potential anti-senescence properties.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $398 | Inquiry | Inquiry | |
| 5 mg | $1,190 | Inquiry | Inquiry | |
| 10 mg | $1,890 | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | Anti-SERPINE1 Antibody is a humanized monoclonal antibody targeting Serpin Family E Member 1 (SERPINE1/PAI-1). SERPINE1, also known as Plasminogen Activator Inhibitor-1 (PAI-1), is the primary physiological inhibitor of tissue-type (tPA) and urokinase-type (uPA) plasminogen activators, playing a critical role in regulating fibrinolysis, cell migration, and tissue remodeling. Elevated PAI-1 levels are associated with thrombosis, fibrosis, metabolic syndrome, and tumor progression (including immune evasion and metastasis). Anti-SERPINE1 Antibody specifically binds to PAI-1, neutralizing its inhibitory activity and restoring tPA/uPA-mediated plasmin generation to promote fibrinolysis and reduce extracellular matrix deposition. Additionally, the antibody blocks PAI-1-mediated upregulation of PD-L1, thereby enhancing anti-tumor immune responses in the tumor microenvironment, and possesses potential anti-senescence properties. |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | SERPINE1 |
| Isotype | IgG1 |
| Storage | Store at low temperature Store at -20°C Shipping with blue ice/Shipping at ambient temperature. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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