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Anti-TIE1 Antibody-PE (6Z404)
🥰Excellent
Catalog No. TMAY-00918P
Anti-TIE1 Antibody-PE (6Z404) is a PE-conjugated Mouse antibody targeting TIE1. Anti-TIE1 Antibody-PE (6Z404) can be used in FCM.
Anti-TIE1 Antibody-PE (6Z404)
Anti-TIE1 Antibody-PE (6Z404)
🥰Excellent
Catalog No. TMAY-00918P
Anti-TIE1 Antibody-PE (6Z404) is a PE-conjugated Mouse antibody targeting TIE1. Anti-TIE1 Antibody-PE (6Z404) can be used in FCM.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-TIE1 Antibody-PE (6Z404) is a PE-conjugated Mouse antibody targeting TIE1. Anti-TIE1 Antibody-PE (6Z404) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG2b |
| Clone | 6Z404 |
| Reactivity | Human |
| Verified Activity | Profile of anti-TIE1 reactivity on HUVEC cells analyzed by flow cytometry. |
| Application | FCM |
| Recommended Dose | 10 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Tie1 (rh Tie1; TMPY-01910; NP_005415.1; Met 1-Gln 760) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| Research Background | Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 also known as Tie1 is an angiopoietin receptor and is an orphan receptor tyrosine kinase that is expressed almost exclusively in endothelial cells and that is required for normal embryonic vascular development. The receptor tyrosine kinase Tie1 is expressed primarily in vascular endothelial cells. The receptor has also been detected in epithelial tumours in breast, thyroid and gastric cancers and in tumour cell lines where it appears as a 45 kDa truncated receptor fragment. Tie1 promotes endothelial cell survival, but other studies have suggested that the Tie1 kinase has little to no activity. Embryos deficient in Tie1 failed to establish structural integrity of vascular endothelial cells, resulting in oedema and subsequently localized haemorrhage. Tie1 is significantly higher in human aortic endothelial cells than in human umbilical vein endothelial cells. Additionally, attachment of cells of monocytic lineage to endothelial cells is also enhanced by Tie1 expression. Collectively Tie1 has a proinflammatory property and may play a role in endothelial inflammatory diseases such as atherosclerosis. |
| Conjucates | PE |
| Others Formats | Unconjugated |
| Antibody Types Available | 2 |
| Immunogen | Recombinant Human Tie1 protein (TMPY-01910) |
| Antigen Species | Human |
| Biology Area | Receptor Tyrosine Kinases (RTKs) |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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