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Tolazamide

Name: Tolazamide
Brand: TargetMol
SKU: T1333
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1333Cas No. 1156-19-0

Alias U-17835

Tolazamide (U-17835) is a sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE.

Tolazamide

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Purity: 99.7%

Catalog No. T1333Alias U-17835Cas No. 1156-19-0

Tolazamide (U-17835) is a sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$48	In Stock	In Stock
10 mg	$64	In Stock	In Stock
25 mg	$98	In Stock	In Stock
50 mg	$127	In Stock	In Stock
100 mg	$163	In Stock	In Stock
200 mg	$243	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$56	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.7%

Color:White

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COA HNMR HPLC

Product Introduction

Tolazamide AI Summary

Tolazamide exhibits significant bioactivities including plasma protein binding, glucose metabolism modulation, enzyme inhibition, liver toxicity, and antiviral and antibacterial properties. It binds strongly to human serum albumin (HSA) with a Log K' value of 0.42 and a plasma protein binding rate of up to 97%. In glucose metabolism, it reduces blood glucose levels in glucose-primed fasted rats and normal fasted guinea pigs in a dose-dependent manner, although it shows no effect in alloxanized diabetic rats. Its LD50 assessment indicates a level of acute toxicity upon both intraperitoneal and oral administration in mice. The compound demonstrates inhibitory effects on various enzymes and pathways, including NFkB signaling, lipoxygenase, and SARS-CoV-2 3CL-Pro protease. Specifically, it inhibits 15-LO enzyme activity with an IC50 of 5106.0 nM and has an antiviral effect demonstrated as inhibition of SARS-CoV-2 induced cytotoxicity in VERO-6 cells. Despite these activities, its effectiveness against SARS-CoV-2 in cell viability inhibition assays is minimal with a low inhibition index of 0.0131 and an IC50 value above 20,000 nM. Tolazamide also poses potential liver toxicity risks, affecting various markers and showing moderately severe drug-induced liver injury (DILI) with a severity class index of 2.0. It possesses a neutral log D value of 0.0 at pH 7.4 and a slightly higher log D value of 1.2 at pH 5.5, indicating moderate hydrophilicity and lipophilicity which impact its distribution and bioavailability. In addition to its metabolic effects, Tolazamide shows broad-spectrum activity against several bacterial and fungal organisms and inhibits human HDAC6 enzyme activity. The compound’s multi-target bioactivities suggest a wide range of potential therapeutic applications and underline the necessity for thorough evaluation in the context of safety and efficacy..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Tolazamide (U-17835) is a sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE.
Synonyms	U-17835

Chemical Properties

Molecular Weight	311.40
Formula	C₁₄H₂₁N₃O₃S
Cas No.	1156-19-0
Smiles	S(NC(NN1CCCCCC1)=O)(=O)(=O)C2=CC=C(C)C=C2
Relative Density.	1.29g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 55 mg/mL (176.62 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2113 mL	16.0565 mL	32.1130 mL	160.5652 mL
5 mM	0.6423 mL	3.2113 mL	6.4226 mL	32.1130 mL
10 mM	0.3211 mL	1.6057 mL	3.2113 mL	16.0565 mL
20 mM	0.1606 mL	0.8028 mL	1.6057 mL	8.0283 mL
50 mM	0.0642 mL	0.3211 mL	0.6423 mL	3.2113 mL
100 mM	0.0321 mL	0.1606 mL	0.3211 mL	1.6057 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc