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Anti-Niemann Pick C1 Like 1 Antibody (1B639)
🥰Excellent
Catalog No. TMAB-09476
Antibody Type: Recombinant Rabbit Monoclonal
Application: WB
Reactivity: Human
Anti-Niemann Pick C1 Like 1 Antibody (1B639)
Anti-Niemann Pick C1 Like 1 Antibody (1B639)
🥰Excellent
Catalog No. TMAB-09476
Antibody Type: Recombinant Rabbit Monoclonal
Application: WB
Reactivity: Human
Application: WB
Reactivity: Human
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Niemann Pick C1 Like 1 Antibody (1B639) is a Rabbit antibody targeting Niemann Pick C1 Like 1. Anti-Niemann Pick C1 Like 1 Antibody (1B639) can be used in WB. |
| Ig Type | IgG |
| Clone | 1B639 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1:1000-2000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Apical cell membrane. Cell membrane. Cytoplasmic vesicle membrane. Subfractionation of brush border membranes from proximal enterocytes suggests considerable association with the apical membrane fraction. Exists as a predominantly cell surface membrane expressed protein (By similarity). According to PubMed:15671032, localizes in a subcellular vesicular compartment rich in RAB5. |
| Tissue Specificity | Widely expressed. Expressed in liver. Also expressed in small intestine, pancreas, kidney, lung, pancreas, spleen, heart, gall bladder, brain, testis, stomach and muscle. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| Research Background | Plays a major role in cholesterol homeostasis.Critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte.Involved in plant sterol absorption, it transports sitosterol, although at lower rates than cholesterol.Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption and is approved for the treatment of hypercholesterolemia. |
| Immunogen | A synthesized peptide: human NPC1L1 |
| Antigen Species | Human |
| Gene Name | NPC1L1 |
| Gene ID | |
| Protein Name | NPC1-like intracellular cholesterol transporter 1 |
| Uniprot ID | |
| Function | Play a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorbtion. Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism. |
| Molecular Weight | Theoretical: 149 kDa. Actual: 149 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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