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N,N'-bis-(azide-PEG3)-chlorocyclohexenyl Cy7

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Catalog No. T18454Cas No. 2107273-84-5

N,N'-bis-(azide-PEG3)-chlorocyclohexenyl Cy7 is a polyethylene glycol (PEG) derived linker compound used for constructing proteolysis targeting chimeras (PROTACs)[1].

N,N'-bis-(azide-PEG3)-chlorocyclohexenyl Cy7

N,N'-bis-(azide-PEG3)-chlorocyclohexenyl Cy7

😃Good
Catalog No. T18454Cas No. 2107273-84-5
N,N'-bis-(azide-PEG3)-chlorocyclohexenyl Cy7 is a polyethylene glycol (PEG) derived linker compound used for constructing proteolysis targeting chimeras (PROTACs)[1].
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Product Introduction

Bioactivity
Description
N,N'-bis-(azide-PEG3)-chlorocyclohexenyl Cy7 is a polyethylene glycol (PEG) derived linker compound used for constructing proteolysis targeting chimeras (PROTACs)[1].
In vitro
PROTACs consist of two ligands connected by a linker: one for an E3 ubiquitin ligase and the other for the target protein. They utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1].
Chemical Properties
Molecular Weight893.94
FormulaC46H62Cl2N8O6
Cas No.2107273-84-5
Smiles[Cl-].[N-]=[N+]=NCCOCCOCCOCCN1C=2C=CC=CC2C(C1=CC=C3C(Cl)=C(C=CC4=[N+](C=5C=CC=CC5C4(C)C)CCOCCOCCOCCN=[N+]=[N-])CCC3)(C)C
Relative Density.1.31g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Keywords

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