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Darunavir Ethanolate

Name: Darunavir Ethanolate
Brand: TargetMol
SKU: T3335
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3335Cas No. 635728-49-3

Alias UIC 94017, TMC114, Darunavir Ethanolate

Darunavir Ethanolate (UIC 94017) is an HIV PROTEASE INHIBITOR that is used in the treatment of AIDS and HIV INFECTIONS. Due to the emergence of ANTIVIRAL DRUG RESISTANCE when used alone, it is administered in combination with other ANTI-HIV AGENTS.

Darunavir Ethanolate

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Purity: 99.86%

Catalog No. T3335Alias UIC 94017, TMC114, Darunavir EthanolateCas No. 635728-49-3

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$31	In Stock	In Stock
10 mg	$48	In Stock	In Stock
25 mg	$73	In Stock	In Stock
50 mg	$113	In Stock	In Stock
100 mg	$168	In Stock	In Stock
200 mg	$249	In Stock	In Stock
500 mg	$419	-	In Stock
1 mL x 10 mM (in DMSO)	$41	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.86%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Darunavir Ethanolate (UIC 94017) is an HIV PROTEASE INHIBITOR that is used in the treatment of AIDS and HIV INFECTIONS. Due to the emergence of ANTIVIRAL DRUG RESISTANCE when used alone, it is administered in combination with other ANTI-HIV AGENTS.
Targets&IC50	HIV-1 protease:1 nM (Ki)
In vivo	Darunavir effectively combats both wild-type and protease inhibitor (PI)-resistant HIV strains, boasting an oral bioavailability of 37%. Its efficacy is significantly enhanced when used in conjunction with ritonavir, which raises its bioavailability to 82%[3].
Synonyms	UIC 94017, TMC114, Darunavir Ethanolate

Chemical Properties

Molecular Weight	593.74
Formula	C₂₉H₄₃N₃O₈S
Cas No.	635728-49-3
Smiles	CCO.[H][C@@]12CCO[C@]1([H])OC[C@@H]2OC(=O)N[C@@H](Cc1ccccc1)[C@H](O)CN(CC(C)C)S(=O)(=O)c1ccc(N)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 93 mg/mL (156.63 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (5.56 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6842 mL	8.4212 mL	16.8424 mL	84.2119 mL
5 mM	0.3368 mL	1.6842 mL	3.3685 mL	16.8424 mL
10 mM	0.1684 mL	0.8421 mL	1.6842 mL	8.4212 mL
20 mM	0.0842 mL	0.4211 mL	0.8421 mL	4.2106 mL
50 mM	0.0337 mL	0.1684 mL	0.3368 mL	1.6842 mL
100 mM	0.0168 mL	0.0842 mL	0.1684 mL	0.8421 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc