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Ethacizine hydrochloride

Name: Ethacizine hydrochloride
Brand: TargetMol
SKU: T11239
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11239Cas No. 57530-40-2

Alias NIK-244 hydrochloride, NIK-244

Ethacizine hydrochloride (NIK-244) has antiarrhythmic activity, and its effects are related to cardiac activity and can be used to study arrhythmias and myocardial infarction.

Ethacizine hydrochloride

🥰Excellent

Purity: 98.08%

Catalog No. T11239Alias NIK-244 hydrochloride, NIK-244Cas No. 57530-40-2

Ethacizine hydrochloride (NIK-244) has antiarrhythmic activity, and its effects are related to cardiac activity and can be used to study arrhythmias and myocardial infarction.

Pack Size	Price	Availability	Quantity
1 mg	$50	In Stock

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Purity:98.08%

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COA LCMS

Product Introduction

Bioactivity

Description	Ethacizine hydrochloride (NIK-244) has antiarrhythmic activity, and its effects are related to cardiac activity and can be used to study arrhythmias and myocardial infarction.
In vivo	Injecting Ethacizine hydrochloride (1-300 ug) directly into the SA node shows negative chronotropic, negative inotropic, and coronary vasodilator effects, as observed in PM preparations[2].
Synonyms	NIK-244 hydrochloride, NIK-244

Chemical Properties

Molecular Weight	449.99
Formula	C₂₂H₂₈ClN₃O₃S
Cas No.	57530-40-2
Smiles	Cl.CCOC(=O)Nc1ccc2Sc3ccccc3N(C(=O)CCN(CC)CC)c2c1
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (200.00 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2223 mL	11.1114 mL	22.2227 mL	111.1136 mL
5 mM	0.4445 mL	2.2223 mL	4.4445 mL	22.2227 mL
10 mM	0.2222 mL	1.1111 mL	2.2223 mL	11.1114 mL
20 mM	0.1111 mL	0.5556 mL	1.1111 mL	5.5557 mL
50 mM	0.0444 mL	0.2222 mL	0.4445 mL	2.2223 mL
100 mM	0.0222 mL	0.1111 mL	0.2222 mL	1.1111 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc