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DHPG
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Catalog No. T11032Cas No. 146255-66-5
Alias (RS)-3,5-DHPG
DHPG ((RS)-3,5-DHPG) is an effective antagonist of mGluR linked to phospholipase D. As an amino acid, it serves as a selective and potent agonist for Group I mGluR (mGluR 1 and mGluR 5) without affecting Group II or Group III mGluRs.
DHPG
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Purity: 99.55%
Catalog No. T11032Alias (RS)-3,5-DHPGCas No. 146255-66-5
DHPG ((RS)-3,5-DHPG) is an effective antagonist of mGluR linked to phospholipase D. As an amino acid, it serves as a selective and potent agonist for Group I mGluR (mGluR 1 and mGluR 5) without affecting Group II or Group III mGluRs.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $43 | In Stock | In Stock | |
| 10 mg | $68 | In Stock | In Stock | |
| 25 mg | $127 | In Stock | - | |
| 50 mg | $231 | In Stock | - |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.55%
Appearance:Solid
Color:Yellow
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Product Introduction
DHPG AI Summary
DHPG exhibits a range of inhibitory bioactivities across various targets and assays. It inhibits RecQ-Like DNA Helicase 1 (RECQ1) with a potency of 39810.7 nM, Aldehyde Dehydrogenase 1 (ALDH1A1) at 37650.5 nM, and Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) at 39810.7 nM. It is also involved in identifying cell-membrane-permeable IMPase inhibitors potentiated with lithium, showing a potency of 5011.9 nM. Additionally, it blocks the interaction between CBF-beta and RUNX1, relevant for the treatment of Acute Myeloid Leukemia, with an inhibition potency of 39810.7 nM. DHPG further inhibits the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) at 39810.7 nM. In assays on rat hippocampal astrocytes, this compound inhibits ASCT2 mediated [3H]-D-serine uptake by equal to or greater than 25.0% at a concentration of 1 mM after 5 minutes. Lastly, it demonstrates inhibitory activity on human HDAC6, with inhibition percentages of 9.39% for a commercial peptide substrate and 5.3% for a custom peptide substrate..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | DHPG ((RS)-3,5-DHPG) is an effective antagonist of mGluR linked to phospholipase D. As an amino acid, it serves as a selective and potent agonist for Group I mGluR (mGluR 1 and mGluR 5) without affecting Group II or Group III mGluRs. |
| Synonyms | (RS)-3,5-DHPG |
| Molecular Weight | 183.16 |
| Formula | C8H9NO4 |
| Cas No. | 146255-66-5 |
| Smiles | O=C(C(C1=CC(O)=CC(O)=C1)N)O |
| Relative Density. | 1.55g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | DMSO: 1 mg/mL (5.46 mM), Sonication is recommended. H2O: 1 mg/mL (5.46 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO/H2O
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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