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DR6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 34.3 kDa and the accession number is A0A024RD71.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 μg | $600 | 7-10 days | |
1 mg | $3,910 | 7-10 days |
Biological Activity | Immobilized Human DR6, His Tag at 0.5 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-DR6 Antibody, hFc Tag with the EC50 of 8.7 ng/ml determined by ELISA. |
Description | DR6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 34.3 kDa and the accession number is A0A024RD71. |
Species | Human |
Expression System | HEK293 Cells |
Tag | C-His |
Accession Number | O75509 |
Synonyms | tumor necrosis factor receptor superfamily, member 21,DR6,CD358,BM-018 |
Construction | Gln42-His349 |
Protein Purity | > 95% as determined by Tris-Bis PAGE |
Molecular Weight | 34.3 kDa (Predicted); 65-80 kDa (Due to glycosylation) |
Endotoxin | Less than 1EU per μg by the LAL method. |
Formulation | Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
Stability & Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
Shipping | In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
Research Background | beta-amyloid precursor protein (APP) and death receptor 6 (DR6, also known as TNFRSF21) activate a widespread caspase-dependent self-destruction program. DR6 is broadly expressed by developing neurons, and is required for normal cell body death and axonal pruning both in vivo and after trophic-factor deprivation in vitro.DR6 is activated locally by an inactive surface ligand(s) that is released in an active form after trophic-factor deprivation. |
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