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DR6 Protein, Human, Recombinant (His)

TargetMol | SPR
Catalog No. TMPY-01341

DR6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 34.3 kDa and the accession number is A0A024RD71.

DR6 Protein, Human, Recombinant (His)

DR6 Protein, Human, Recombinant (His)

TargetMol | SPR
Catalog No. TMPY-01341
DR6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 34.3 kDa and the accession number is A0A024RD71.
Pack SizePriceAvailabilityQuantity
100 μg$6007-10 days
1 mg$3,9107-10 days
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Product Information

Biological Activity
Immobilized Human DR6, His Tag at 0.5 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-DR6 Antibody, hFc Tag with the EC50 of 8.7 ng/ml determined by ELISA.
Description
DR6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 34.3 kDa and the accession number is A0A024RD71.
Species
Human
Expression System
HEK293 Cells
TagC-His
Accession NumberO75509
Synonyms
tumor necrosis factor receptor superfamily, member 21,DR6,CD358,BM-018
Construction
Gln42-His349
Protein Purity
> 95% as determined by Tris-Bis PAGE
Molecular Weight34.3 kDa (Predicted); 65-80 kDa (Due to glycosylation)
EndotoxinLess than 1EU per μg by the LAL method.
FormulationLyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & Storage
It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
ShippingIn general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background
beta-amyloid precursor protein (APP) and death receptor 6 (DR6, also known as TNFRSF21) activate a widespread caspase-dependent self-destruction program. DR6 is broadly expressed by developing neurons, and is required for normal cell body death and axonal pruning both in vivo and after trophic-factor deprivation in vitro.DR6 is activated locally by an inactive surface ligand(s) that is released in an active form after trophic-factor deprivation.

Dose Conversion

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