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Anti-Endoglin/CD105 Antibody (8I701)
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Catalog No. TMAY-00358
Alias S-endoglin, endoglin, Endo, CD105, AI662476, AI528660
Anti-Endoglin/CD105 Antibody (8I701) is a Mouse antibody targeting Endoglin/CD105. Anti-Endoglin/CD105 Antibody (8I701) can be used in ELISA,IHC-P.
Anti-Endoglin/CD105 Antibody (8I701)
Anti-Endoglin/CD105 Antibody (8I701)
😃Good
Catalog No. TMAY-00358Alias S-endoglin, endoglin, Endo, CD105, AI662476, AI528660
Anti-Endoglin/CD105 Antibody (8I701) is a Mouse antibody targeting Endoglin/CD105. Anti-Endoglin/CD105 Antibody (8I701) can be used in ELISA,IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Chemical Properties
| Description | Anti-Endoglin/CD105 Antibody (8I701) is a Mouse antibody targeting Endoglin/CD105. Anti-Endoglin/CD105 Antibody (8I701) can be used in ELISA,IHC-P. |
| Alias | S-endoglin, endoglin, Endo, CD105, AI662476, AI528660 |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 8I701 |
| Reactivity | Human |
| Verified Activity | 1. Immunochemical staining of human CD105 in human renal carcinoma with mouse monoclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections. 2. Immunochemical staining of human CD105 in human tonsil with mouse monoclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections. 3. Immunochemical staining of human CD105 in human liver with mouse monoclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections. |
| Application | ELISA,IHC-P |
| Recommended Dose | ELISA: 1:1000-1:2000; IHC-P: 1:200-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Endoglin / CD105 (rh Endoglin / CD105 ; TMPY-01384; NP_001108225.1; Met1-Gly586). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Endoglin, also known as CD105, is a type I homodimeric transmembrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated cytoplasmic tail. Endoglin contains an RGD tripeptide which is a key recognition structure in cellular adhesion,,suggesting a critical role for endoglin in the binding of endothelial cells to integrins and/or other RGD receptors. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, mesenchymal stem cells and leukemic cells of lymphoid and myeloid lineages. As an accessory receptor for the TGF-β superfamily ligands, endoglin binds TGF-β1 and TGF-β3 with high affinity not by itself but by associating with TGF-β type II receptor (TβRII) and activates the downstream signal pathways. In addition, in human umbilical vein endothelial cells, ALK-1 is also a receptor kinase for endoglin threonine phosphorylation, and mutations in either of the two genes result in the autosomal-dominant vascular dysplasia, hereditary hemorrhagic telangiectasia (HHT). Endoglin has been regarded as a powerful biomarker of neovascularization, and is associated with several solid tumor types. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human Endoglin / CD105 Protein (TMPY-01384) |
| Antigen Species | Human |
| Biology Area | Hemangioblast Markers, Cancer Drug Targets |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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