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Anti-Phospho-RIPK2 (Ser176) Polyclonal Antibody

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Catalog No. TMAC-03613

Anti-Phospho-RIPK2 (Ser176) Polyclonal Antibody is a Rabbit antibody targeting Phospho-RIPK2 (Ser176). Anti-Phospho-RIPK2 (Ser176) Polyclonal Antibody can be used in WB,IHC.

Anti-Phospho-RIPK2 (Ser176) Polyclonal Antibody

Anti-Phospho-RIPK2 (Ser176) Polyclonal Antibody

😃Good
Catalog No. TMAC-03613
Anti-Phospho-RIPK2 (Ser176) Polyclonal Antibody is a Rabbit antibody targeting Phospho-RIPK2 (Ser176). Anti-Phospho-RIPK2 (Ser176) Polyclonal Antibody can be used in WB,IHC.
Pack SizePriceAvailabilityQuantity
50 μL$2177-10 days
100 μL$3177-10 days
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Product Introduction

Bioactivity
Description
Anti-Phospho-RIPK2 (Ser176) Polyclonal Antibody is a Rabbit antibody targeting Phospho-RIPK2 (Ser176). Anti-Phospho-RIPK2 (Ser176) Polyclonal Antibody can be used in WB,IHC.
Ig Type
IgG
Reactivity
Human,Mouse
Application
Recommended Dose
WB: 1:500-3000; IHC: 1:50-100
Antibody Type
Polyclonal
Host SpeciesRabbit
ConstructionPolyclonal Antibody
PurificationAntibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
AppearanceLiquid
FormulationRabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Research BackgroundSerine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
Phospho
Antigen Details
Immunogen
Peptide sequence around phosphorylation site of serine 176 (S-L-S(p)-Q-S) derived from Human RIPK2
Antigen Species
human
Uniprot ID
Chemical Properties
Molecular WeightActual: 70 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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