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Narcissin

Name: Narcissin
Brand: TargetMol
SKU: T6S1768
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6S1768Cas No. 604-80-8

Alias Narcissoside, Isorhamnetin 3-Rutinoside

Narcissin (Isorhamnetin 3-Rutinoside), with synergism of B.flavum flavonoid and rutin, could be responsible for stronger protection against mitochondrial induced oxidative stress.

Narcissin

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Purity: 99.91%

Catalog No. T6S1768Alias Narcissoside, Isorhamnetin 3-RutinosideCas No. 604-80-8

Narcissin (Isorhamnetin 3-Rutinoside), with synergism of B.flavum flavonoid and rutin, could be responsible for stronger protection against mitochondrial induced oxidative stress.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$41	In Stock	In Stock
5 mg	$90	In Stock	In Stock
10 mg	$128	In Stock	In Stock
25 mg	$215	In Stock	In Stock
50 mg	$318	In Stock	In Stock
100 mg	$469	-	In Stock
1 mL x 10 mM (in DMSO)	$133	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.91%

Color:White to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Narcissin AI Summary

Narcissin exhibits a variety of bioactivities with notable potential in different biological contexts. It shows significant inhibitory effects on mushroom tyrosinase with a 13.13% inhibition rate at 0.053 mM, and vasorelaxation activity in Sprague-Dawley rat aortic tissue with an IC50 value of 16800.0 nM, suggesting its potential in blood pressure management. Notably, it inhibits cow milk xanthine oxidase by 22.2% at 50 ug/mL. The compound also presents strong antiprotozoal activities, including an IC50 value of 17.2 ug/mL against Entamoeba histolytica trophozoites and 94.7 ug/mL against Giardia lamblia. Additionally, it inhibits TPA-induced EBV-early antigen activation in human Raji cells, with noted cytotoxic effects. As an antioxidant, Narcissin scavenges peroxynitrite radicals with IC50 values of 3800.0 nM and 9600.0 nM for authentic and 3-morpholinosydnonimine-derived peroxynitrite radicals, respectively. It shows weak inhibition of CYP3A4 with an IC50 value greater than 80000.0 nM and exhibits estrogenic activity in human MVLN cells, displaying over 83% activity comparable to E2 at certain concentrations. Further, it inhibits advanced glycation end-products formation and has an IC50 of over 50000.0 nM for rat lens aldose reductase inhibition. Antimicrobial efficacy is evidenced by its impact on Streptococcus mutans, with a MIC greater than 320,200.0 nM and sortase A inhibition with an IC50 of 62,100.0 nM. Although it exhibits inhibitory effects on IL-12 p40, IL-6, and TNF-alpha production, it has an IC50 value greater than 50,000 nM, indicating lower potency. Finally, the compound exerts antineuroinflammatory activities by inhibiting nitric oxide production in both human BV2 and mouse N9 cells induced by LPS, but shows significant cytotoxicity in BV2 cells..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Narcissin (Isorhamnetin 3-Rutinoside), with synergism of B.flavum flavonoid and rutin, could be responsible for stronger protection against mitochondrial induced oxidative stress.
Synonyms	Narcissoside, Isorhamnetin 3-Rutinoside

Chemical Properties

Molecular Weight	624.54
Formula	C₂₈H₃₂O₁₆
Cas No.	604-80-8
Smiles	COc1cc(ccc1O)-c1oc2cc(O)cc(O)c2c(=O)c1O[C@@H]1O[C@H](CO[C@@H]2O[C@@H](C)[C@H](O)[C@@H](O)[C@H]2O)[C@@H](O)[C@H](O)[C@H]1O
Relative Density.	1.74 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: Soluble

DMSO: 127.5 mg/mL (204.15 mM), Sonication is recommended.

Pyridine, Methanol, etc.: Soluble

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (5.28 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6012 mL	8.0059 mL	16.0118 mL	80.0589 mL
5 mM	0.3202 mL	1.6012 mL	3.2024 mL	16.0118 mL
10 mM	0.1601 mL	0.8006 mL	1.6012 mL	8.0059 mL
20 mM	0.0801 mL	0.4003 mL	0.8006 mL	4.0029 mL
50 mM	0.0320 mL	0.1601 mL	0.3202 mL	1.6012 mL
100 mM	0.0160 mL	0.0801 mL	0.1601 mL	0.8006 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc