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Anti-CD55/DAF Antibody-APC (7N765)
🥰Excellent
Catalog No. TMAY-00258A
Anti-CD55/DAF Antibody-APC (7N765) is a APC-conjugated Rabbit antibody targeting CD55/DAF. Anti-CD55/DAF Antibody-APC (7N765) can be used in FCM.
Anti-CD55/DAF Antibody-APC (7N765)
Anti-CD55/DAF Antibody-APC (7N765)
🥰Excellent
Catalog No. TMAY-00258A
Anti-CD55/DAF Antibody-APC (7N765) is a APC-conjugated Rabbit antibody targeting CD55/DAF. Anti-CD55/DAF Antibody-APC (7N765) can be used in FCM.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-CD55/DAF Antibody-APC (7N765) is a APC-conjugated Rabbit antibody targeting CD55/DAF. Anti-CD55/DAF Antibody-APC (7N765) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 7N765 |
| Reactivity | Human |
| Verified Activity | Profile of anti-CD55 reactivity on K562 cells analyzed by flow cytometry. |
| Application | FCM |
| Recommended Dose | 5 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human CD55 / DAF (rh CD55 / DAF; TMPY-01292; NP_000565.1; Met 1-Ser 353) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Research Background | CD55, also well known as decay-accelerating factor (DAF), is a member of the RCA (regulators of complement activation) family characterized by four to 30 SCRs (short consensus repeats) in their plasma-exposed regions. It is a major regulator of the alternative and classical pathways of complement activation and is expressed on all serum-exposed cells. CD55 is physiologically acting as an inhibitor of the complement system, but is also broadly expressed in malignant tumours. DAF seems to exert different functions beyond its immunological role such as promotion of tumorigenesis, decrease of complement mediated tumor cell lysis, autocrine loops for cell rescue and evasion of apoptosis, neoangiogenesis, invasiveness, cell motility. It is commonly hijacked by invading pathogens, including many enteroviruses and uropathogenic Escherichia coli, to promote cellular attachment prior to infection. This 70-75 kDa glycoprotein CD55 containing four SCR modules is involved in the regulation of the complement cascade. It inhibits complement activation by suppressing the function of C3/C5 convertases, thereby limiting local generation or deposition of C3a/C5a and membrane attack complex (MAC or C5b-9) production. DAF has been identified as a ligand for an activation-associated, seven-transmembrane lymphocyte receptor, CD97, which is a receptor mediating attachment and infection of several viruses and bacteria. In addition, it has been shown that DAF regulates the interplay between complement and T cell immunity in vivo, and thus may be implicated in immune and tumor biology. |
| Conjucates | APC |
| Others Formats | Unconjugated/PerCP/FITC/PE |
| Antibody Types Available | 5 |
| Immunogen | Recombinant Human CD55 / DAF protein (TMPY-01292) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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