TRAIL/TNFSF10 Protein, Mouse, Recombinant

Name: TRAIL/TNFSF10 Protein, Mouse, Recombinant
Brand: TargetMol
SKU: TMPS-00180
Price: 56 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: Tumor necrosis factor ligand superfamily member 10, Tnfsf10, TNF-related apoptosis-inducing ligand, Protein TRAIL, CD_antigen: CD253) Copy Product Info

Synonyms: Tumor necrosis factor ligand superfamily member 10, Tnfsf10, TNF-related apoptosis-inducing ligand, Protein TRAIL, CD_antigen: CD253

Catalog No. TMPS-00180 Copy Product Info

TRAIL/TNFSF10 Protein, Mouse, Recombinant is expressed in E. coli. The accession number is P50592.

Pack Size	Price	USA Stock	Global Stock
5 µg	$56	-	In Stock
10 µg	$88	-	In Stock
20 µg	$123	7-10 days	7-10 days
50 µg	$196	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:> 98% as analyzed by SDS-PAGE

Appearance:Lyophilized powder

Color:White

Resource Download

COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	ED 50 < 100.0 ng/ml, measured by the cell growth inhibitory assay using RPMI-8226 cells, corresponding to a specific activity of > 1.0 × 10 4 units/mg.
Description	TRAIL/TNFSF10 Protein, Mouse, Recombinant is expressed in E. coli. The accession number is P50592.
Species	Mouse
Expression System	E. coli
Tag	Tag Free
Accession Number	P50592
Construction	Arg119-Asn291
Protein Purity	> 98% as determined by SDS-PAGE
Endotoxin	< 0.2 EU/μg of protein as determined by the LAL method.
Formulation	Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution	Reconstitute the lyophilized protein in sterile deionized water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	Tumor necrosis factor ligand superfamily member 10, Tnfsf10, TNF-related apoptosis-inducing ligand, Protein TRAIL, CD_antigen: CD253
Research Background	TNF-related apoptosis-inducing ligand (TRAIL), also known as Tumor Necrosis Factor Super-Family 10 (TNFSF10) or apoptosis 2 ligand (Apo2L), is a pleiotropic cytokine thatbelongs to the TNF superfamily. Full length TRAIL expressed in vivo is a type II transmembrane protein, although the soluble form also exists and functions. TRAIL has four major receptors: two death receptors DR4 and DR5, and two decoy receptors DcR1 and DcR2. TRAIL binds to the death receptors which recruits the FAS-associated death domain and activates caspases 8 and 10 which eventually leads to apoptosis. Because of its antitumor potential, TRAIL is activelystudied as a therapeutic agent. On the other hand, abnormal expression of TRAIL in small arteries can induce the proliferation of smooth muscle cells, thereby increasing vascular remodeling and pulmonary arterial hypertension.

Chemical Properties

Molecular Weight

~20 kDa (Reducing conditions)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.