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Phe-Met-Arg-Phe, amide acetate

🥰Excellent
Catalog No. TP1858L
Alias Phe-Met-Arg-Phe, amide acetate(64190-70-1 freebase)

Phe-Met-Arg-Phe, amide acetate, activates a K+ current in peptidergic caudodorsal neurons dose-dependently (ED50=23 nM) and appears to localize with neuropeptide Y in some brain regions.

Phe-Met-Arg-Phe, amide acetate
Other Forms of Phe-Met-Arg-Phe, amide acetate:
Phe-Met-Arg-Phe, amideTP185864190-70-1
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Phe-Met-Arg-Phe, amide acetate

🥰Excellent
Purity: 99.4%
Catalog No. TP1858LAlias Phe-Met-Arg-Phe, amide acetate(64190-70-1 freebase)
Phe-Met-Arg-Phe, amide acetate, activates a K+ current in peptidergic caudodorsal neurons dose-dependently (ED50=23 nM) and appears to localize with neuropeptide Y in some brain regions.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$46In StockIn Stock
2 mg$64In StockIn Stock
5 mg$91In StockIn Stock
10 mg$147In StockIn Stock
25 mg$292In StockIn Stock
50 mg$438In StockIn Stock
100 mg$647In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.4%
Appearance:Solid
Color:White
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
Phe-Met-Arg-Phe, amide acetate, activates a K+ current in peptidergic caudodorsal neurons dose-dependently (ED50=23 nM) and appears to localize with neuropeptide Y in some brain regions.
Targets&IC50
K+ current (IKr):ED50: 23 nM
In vitro
In the molluscan central nervous system, Phe-Met-Arg-Phe, amide (FMRFa) acts on K+ channels in sensory, motor-, and neuroendocrine neurons and activates a novel K+ current characterized by a combined voltage- and receptor-dependent gating mechanism, with both factors necessary for channel opening[1]. At 1 μM, it significantly inhibits glucose-stimulated (300 mg/dL) insulin release (p<0.005) and somatostatin release (p<0.01) from the isolated perfused pancreas. Phe-Met-Arg-Phe, amide (FMRF-NH2) (1 and 10 μM) has no effect on glucagon secretion, whether in low glucose (50 mg/dL), high glucose (300 mg/dL), or during arginine stimulation (5 mM)[2].
In vivo
Phe-Met-Arg-Phe amide (FMRFamide) has been identified to stimulate growth hormone secretion in conscious ovariectomized (OVX) rats. Its immunoreactivity within hypothalamic neuronal elements hints at its involvement in regulating anterior pituitary functions. Administration of 200 ng (313.8 picomoles) of FMRFamide in a 2 uL volume significantly elevates plasma growth hormone (GH) levels within 15 minutes post-injection. Moreover, a dose range of 400-800 ng (627-1255 picomoles) of FMRFamide induces a rapid increase in GH levels, observable as early as 5 minutes and persisting for up to 30 minutes.
SynonymsPhe-Met-Arg-Phe, amide acetate(64190-70-1 freebase)
Chemical Properties
Molecular Weight658.82
FormulaC31H46N8O6S
SmilesO=C(C)O.CSCC[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N)NC(=O)[C@H](CC2=CC=CC=C2)N
Relative Density.no data available
SequencePhe-Met-Arg-Phe-NH2
Sequence ShortFMRF
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 10 mM, Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.5179 mL7.5893 mL15.1787 mL75.8933 mL
5 mM0.3036 mL1.5179 mL3.0357 mL15.1787 mL
10 mM0.1518 mL0.7589 mL1.5179 mL7.5893 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

PotassiumChannelPotassium ChannelPhe-Met-Arg-Phe, amide AcetatePheMetArgPhe, amide acetatePhe Met Arg Phe, amide acetateK+ current (IKr)64190-70-1 freebase
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