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Anti-Apaf-1 Antibody (9E241)

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Catalog No. TMAC-00235

Anti-Apaf-1 Antibody (9E241) is a Rabbit antibody targeting Apaf-1. Anti-Apaf-1 Antibody (9E241) can be used in WB,ICC/IF,IHC.

Anti-Apaf-1 Antibody (9E241)

Anti-Apaf-1 Antibody (9E241)

😃Good
Catalog No. TMAC-00235
Anti-Apaf-1 Antibody (9E241) is a Rabbit antibody targeting Apaf-1. Anti-Apaf-1 Antibody (9E241) can be used in WB,ICC/IF,IHC.
Pack SizePriceAvailabilityQuantity
50 μL$2987-10 days
100 μL$4987-10 days
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Product Introduction

Bioactivity
Description
Anti-Apaf-1 Antibody (9E241) is a Rabbit antibody targeting Apaf-1. Anti-Apaf-1 Antibody (9E241) can be used in WB,ICC/IF,IHC.
Ig Type
IgG
Reactivity
Human,Mouse
Application
Recommended Dose
WB: 1:1000; IHC: 1:50-200; ICC/IF: 1:50-200
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionRecombinant Antibody
PurificationProA affinity purified
AppearanceLiquid
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Research BackgroundThe mammalian homologs of the Ced-4 proteins, Apaf-1 (Ced-4), Nod1 (CARD4), and Nod2 contain a caspase recruitment domain (CARD) and a putative nucleotide binding domain, signified by a consensus Walker's A box (P-loop) and B box (Mg2+-binding site). Nod1 contains a putative regulatory domain and multiple leucine-rich repeats. Nod1 is a member of a growing family of intracellular proteins which share structural homology to the apoptosis regulator Apaf-1. Nod1 associates with the CARD-containing kinase RICK and activates NFkB. The self-association of Nod1 mediates proximity of RICK and the interaction of RICK with IKKg. In addition, Nod-1 binds to multiple caspases with long prodomains, but specifically activates caspase-9 and promotes caspase-9-induced apoptosis. Nod2 is composed of two N-terminal CARDs, a nucleotide-binding domain, and multiple C-terminal leucine-rich repeats. The expression of Nod2 is highly restricted to monocytes, and activates NFkB in response to bacterial lipopoly-saccharides.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Protein
Antigen Species
Recombinant Protein
Uniprot ID
Chemical Properties
Molecular WeightTheoretical: 141 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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