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FBA-IN-1

Name: FBA-IN-1
Brand: TargetMol
SKU: T60684
Price: 149 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T60684Cas No. 2605897-57-0

FBA-IN-1 (compound 2a11) is a first-in-class, covalent, and allosteric inhibitor of fructose-1,6-bisphosphate aldolase (FBA) from Candida albicans (CaFBA). Additionally, FBA-IN-1 inhibits the growth of Azole-resistant strains 103 with an MIC 80 of 1 μg/mL [1].

FBA-IN-1

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Purity: 98.79%

Catalog No. T60684Cas No. 2605897-57-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$149	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.79%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description

In vitro

METHODS: Using a structure-based optimization strategy, we discovered a novel covalent binding site (site C292) and a first-in-class covalent allosteric inhibitor of FBA from Candida albicans (CaFBA). In addition, the inhibitory activity of FBA-IN-1 inhibitor against azole-resistant Candida albicans was tested.
RESULTS: FBA-IN-1 could inhibit the growth of azole-resistant strain 103 with a MIC80 of 1 μg/mL. [1]

Chemical Properties

Molecular Weight	302.23
Formula	C₁₅H₁₃NOSe
Cas No.	2605897-57-0
Smiles	O=C1C=2C=CC=CC2[Se]N1C3=CC=C(C=C3)CC

Storage & Solubility Information

Storage

store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (264.7 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (10.92 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3087 mL	16.5437 mL	33.0874 mL	165.4369 mL
5 mM	0.6617 mL	3.3087 mL	6.6175 mL	33.0874 mL
10 mM	0.3309 mL	1.6544 mL	3.3087 mL	16.5437 mL
20 mM	0.1654 mL	0.8272 mL	1.6544 mL	8.2718 mL
50 mM	0.0662 mL	0.3309 mL	0.6617 mL	3.3087 mL
100 mM	0.0331 mL	0.1654 mL	0.3309 mL	1.6544 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc