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FBA-IN-1

🥰Excellent
Catalog No. T60684Cas No. 2605897-57-0

FBA-IN-1 (compound 2a11) is a first-in-class, covalent, and allosteric inhibitor of fructose-1,6-bisphosphate aldolase (FBA) from Candida albicans (CaFBA). Additionally, FBA-IN-1 inhibits the growth of Azole-resistant strains 103 with an MIC 80 of 1 μg/mL [1].

FBA-IN-1

FBA-IN-1

🥰Excellent
Purity: 98.79%
Catalog No. T60684Cas No. 2605897-57-0
FBA-IN-1 (compound 2a11) is a first-in-class, covalent, and allosteric inhibitor of fructose-1,6-bisphosphate aldolase (FBA) from Candida albicans (CaFBA). Additionally, FBA-IN-1 inhibits the growth of Azole-resistant strains 103 with an MIC 80 of 1 μg/mL [1].
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1 mg$149-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:98.79%
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Product Introduction

Bioactivity
Description
FBA-IN-1 (compound 2a11) is a first-in-class, covalent, and allosteric inhibitor of fructose-1,6-bisphosphate aldolase (FBA) from Candida albicans (CaFBA). Additionally, FBA-IN-1 inhibits the growth of Azole-resistant strains 103 with an MIC 80 of 1 μg/mL [1].
In vitro
METHODS: Using a structure-based optimization strategy, we discovered a novel covalent binding site (site C292) and a first-in-class covalent allosteric inhibitor of FBA from Candida albicans (CaFBA). In addition, the inhibitory activity of FBA-IN-1 inhibitor against azole-resistant Candida albicans was tested.
RESULTS: FBA-IN-1 could inhibit the growth of azole-resistant strain 103 with a MIC80 of 1 μg/mL. [1]
Chemical Properties
Molecular Weight302.23
FormulaC15H13NOSe
Cas No.2605897-57-0
SmilesO=C1C=2C=CC=CC2[Se]N1C3=CC=C(C=C3)CC
Storage & Solubility Information
Storagestore at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (264.70 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (10.92 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.3087 mL16.5437 mL33.0874 mL165.4369 mL
5 mM0.6617 mL3.3087 mL6.6175 mL33.0874 mL
10 mM0.3309 mL1.6544 mL3.3087 mL16.5437 mL
20 mM0.1654 mL0.8272 mL1.6544 mL8.2718 mL
50 mM0.0662 mL0.3309 mL0.6617 mL3.3087 mL
100 mM0.0331 mL0.1654 mL0.3309 mL1.6544 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Fungal
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