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p-Ethynylphenylalanine

Name: p-Ethynylphenylalanine
Brand: TargetMol
SKU: T10142
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10142Cas No. 278605-15-5

Alias 4-Ethynyl-L-phenylalanine

p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine), a selective, effective, and reversible tryptophan hydroxylase (TPH) inhibitor, exhibits competitive inhibition with a Ki of 32.6 μM.

p-Ethynylphenylalanine

🥰Excellent

Purity: 97.57%

Catalog No. T10142Alias 4-Ethynyl-L-phenylalanineCas No. 278605-15-5

p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine), a selective, effective, and reversible tryptophan hydroxylase (TPH) inhibitor, exhibits competitive inhibition with a Ki of 32.6 μM.

Pack Size	Price	Availability
10 mg	$34	In Stock
25 mg	$55	In Stock
50 mg	$80	In Stock
1 mL x 10 mM (in DMSO)	$89	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:97.57%

ee:100%

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Product Introduction

Bioactivity

Description	p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine), a selective, effective, and reversible tryptophan hydroxylase (TPH) inhibitor, exhibits competitive inhibition with a Ki of 32.6 μM.
Targets&IC50	TPH:32.6 μM (Ki), TPH:ki:32.6 μM
In vivo	4-Ethynyl-L-phenylalanine (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue. It is not inhibiting the aromatic amino acid decarboxylase. It has a low affinity for various recombinant 5-HT receptors.
Synonyms	4-Ethynyl-L-phenylalanine

Chemical Properties

Molecular Weight	189.21
Formula	C₁₁H₁₁NO₂
Cas No.	278605-15-5
Smiles	N[C@@H](Cc1ccc(cc1)C#C)C(O)=O
Relative Density.	1.21 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

1M HCl: 216.0 mg/mL (1141.6 mM), when pH is adjusted to 1 with HCl. Sonication is recommended.

DMSO: 2.0 mg/mL (10.6 mM), Sonication is recommended.

1M NaOH: 216.0 mg/mL (1141.6 mM), when pH is adjusted to 11 with NaOH. Sonication is recommended.

Solution Preparation Table

DMSO/1M HCl/1M NaOH

	1mg	5mg	10mg	50mg
1 mM	5.2851 mL	26.4257 mL	52.8513 mL	264.2566 mL
5 mM	1.0570 mL	5.2851 mL	10.5703 mL	52.8513 mL
10 mM	0.5285 mL	2.6426 mL	5.2851 mL	26.4257 mL

1M HCl/1M NaOH

	1mg	5mg	10mg	50mg
20 mM	0.2643 mL	1.3213 mL	2.6426 mL	13.2128 mL
50 mM	0.1057 mL	0.5285 mL	1.0570 mL	5.2851 mL
100 mM	0.0529 mL	0.2643 mL	0.5285 mL	2.6426 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc