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Mevociclib

Name: Mevociclib
Brand: TargetMol
SKU: T13044
Price: 199 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13044Cas No. 1816989-16-8

Alias SY-1365

Mevociclib (SY-1365) is a highly selective covalent inhibitor of CDK7, possessing therapeutic potential in both hematological and solid tumors.

Mevociclib

🥰Excellent

Purity: 98.02%

Catalog No. T13044Alias SY-1365Cas No. 1816989-16-8

Mevociclib (SY-1365) is a highly selective covalent inhibitor of CDK7, possessing therapeutic potential in both hematological and solid tumors.

Pack Size	Price	Availability	Quantity
1 mg	$199	In Stock

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Purity:98.02%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Mevociclib (SY-1365) is a highly selective covalent inhibitor of CDK7, possessing therapeutic potential in both hematological and solid tumors.
Synonyms	SY-1365

Chemical Properties

Molecular Weight	587.11
Formula	C₃₁H₃₅ClN₈O₂
Cas No.	1816989-16-8
Smiles	CN(C)C\C=C\C(=O)Nc1ccc(nc1)C(=O)N[C@@]1(C)CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12
Relative Density.	1.34 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (212.90 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7033 mL	8.5163 mL	17.0326 mL	85.1629 mL
5 mM	0.3407 mL	1.7033 mL	3.4065 mL	17.0326 mL
10 mM	0.1703 mL	0.8516 mL	1.7033 mL	8.5163 mL
20 mM	0.0852 mL	0.4258 mL	0.8516 mL	4.2581 mL
50 mM	0.0341 mL	0.1703 mL	0.3407 mL	1.7033 mL
100 mM	0.0170 mL	0.0852 mL	0.1703 mL	0.8516 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc