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Dicloxacillin Sodium hydrate

Name: Dicloxacillin Sodium hydrate
Brand: TargetMol
SKU: T1001
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1001Cas No. 13412-64-1

Alias Dicloxacillin sodium salt monohydrate, Dicloxacillin sodium monohydrate

Dicloxacillin Sodium hydrate is a narrow-spectrum β-Lactam antibiotic of the penicillin class, used to treat infections caused by susceptible Gram-positive bacteria.

Dicloxacillin Sodium hydrate

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Purity: 97.77%

Catalog No. T1001Alias Dicloxacillin sodium salt monohydrate, Dicloxacillin sodium monohydrateCas No. 13412-64-1

Dicloxacillin Sodium hydrate is a narrow-spectrum β-Lactam antibiotic of the penicillin class, used to treat infections caused by susceptible Gram-positive bacteria.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$38	In Stock	In Stock
50 mg	$50	In Stock	In Stock
100 mg	$72	In Stock	In Stock
200 mg	$97	In Stock	-

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:97.77%

Color:White

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Product Introduction

Dicloxacillin Sodium hydrate AI Summary

Dicloxacillin Sodium hydrate exhibits a broad spectrum of bioactivities, showcasing inhibitory potency across various biochemical targets. It shows significant inhibition of AmpC Beta-Lactamase with a potency of 44.7 nM and moderate inhibition of HP1-beta Chromodomain interactions with methylated histone tails at 3548.1 nM. The compound acts as a delayed death inhibitor for the malarial parasite plastid at 18526.0 nM and has an AC50 of 46690.0 nM for Schnurri-3, implicating its potential in adult bone formation. Additionally, it inhibits Glutaminase (GLS) at 5623.4 nM. In antiviral assays, Dicloxacillin Sodium hydrate displays varying potencies against Ebola Virus entry, with AC50 values ranging from 1.259 μM to 44.67 μM. It inhibits sodium fluorescein uptake in OATP1B3 and OATP1B1-transfected CHO cells with pIC50 values of 1995.26 nM and 676.08 nM, respectively, and corresponding Ki values of 1550.0 nM and 370.0 nM. In SARS-CoV-2 assays, the compound shows 14.02% inhibition of the 3CL-Pro protease at 20 μM and an inhibition rate of 12.15% in Caco-2 cell cytotoxicity assays at 10 μM after 48 hours. However, it displays minimal activity in Vero E6 cells with a negative inhibition index for cell viability relative to arbidol control, and only 0.19% inhibition in VERO-6 cells at 10 μM after 48 hours. Overall, Dicloxacillin Sodium hydrate demonstrates a diverse profile of antimicrobial, antimalarial, bone formation modulation, and antiviral properties with varying degrees of efficacy..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Dicloxacillin Sodium hydrate is a narrow-spectrum β-Lactam antibiotic of the penicillin class, used to treat infections caused by susceptible Gram-positive bacteria.
Synonyms	Dicloxacillin sodium salt monohydrate, Dicloxacillin sodium monohydrate

Chemical Properties

Molecular Weight	510.32
Formula	C₁₉H₁₈Cl₂N₃NaO₆S
Cas No.	13412-64-1
Smiles	[O-]C([C@@H]1N2[C@@](SC1(C)C)([H])[C@@H](C2=O)NC(C3=C(C)ON=C3C4=C(C=CC=C4Cl)Cl)=O)=O.[Na+].O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 22.73 mg/mL (44.54 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.9596 mL	9.7978 mL	19.5955 mL	97.9777 mL
5 mM	0.3919 mL	1.9596 mL	3.9191 mL	19.5955 mL
10 mM	0.1960 mL	0.9798 mL	1.9596 mL	9.7978 mL
20 mM	0.0980 mL	0.4899 mL	0.9798 mL	4.8989 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc