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Fidarestat

Name: Fidarestat
Brand: TargetMol
SKU: T15281
Price: 399 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15281Cas No. 136087-85-9

Alias SNK860, SNK 860

Fidarestat (SNK 860), an aldose reductase inhibitor, exhibits IC50 values of 26 nM, 33 μM, and 1.8 μM against aldose reductase, AKR1B10, and V301L AKR1B10 respectively, demonstrating potential for diabetes treatment.

Fidarestat

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Catalog No. T15281Alias SNK860, SNK 860Cas No. 136087-85-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$50	-	In Stock
5 mg	$249	-	In Stock
10 mg	$399	-	In Stock
25 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$199	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	Fidarestat (SNK 860), an aldose reductase inhibitor, exhibits IC50 values of 26 nM, 33 μM, and 1.8 μM against aldose reductase, AKR1B10, and V301L AKR1B10 respectively, demonstrating potential for diabetes treatment.
Targets&IC50	AKR1B10 (V301L):1.8 μM, Aldose reductase:26 nM, AKR1B10:33 μM
In vivo	Fidarestat (1 or 4 mg/kg, orally, daily, for 4 weeks) treatment of diabetic rats reduced sorbitol and fructose concentrations in diabetic rats.[1]
Synonyms	SNK860, SNK 860

Chemical Properties

Molecular Weight	279.22
Formula	C₁₂H₁₀FN₃O₄
Cas No.	136087-85-9
Smiles	O=C1[C@]2(C=3C(O[C@H](C(N)=O)C2)=CC=C(F)C3)NC(=O)N1
Relative Density.	1.61 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (358.14 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (14.33 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5814 mL	17.9070 mL	35.8141 mL	179.0703 mL
5 mM	0.7163 mL	3.5814 mL	7.1628 mL	35.8141 mL
10 mM	0.3581 mL	1.7907 mL	3.5814 mL	17.9070 mL
20 mM	0.1791 mL	0.8954 mL	1.7907 mL	8.9535 mL
50 mM	0.0716 mL	0.3581 mL	0.7163 mL	3.5814 mL
100 mM	0.0358 mL	0.1791 mL	0.3581 mL	1.7907 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc