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Ginsenoside Rb1

Name: Ginsenoside Rb1
Brand: TargetMol
SKU: T2822
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2822Cas No. 41753-43-9

Alias Gypenoside III, Gypenoside Ⅲ

Ginsenoside Rb1 (Gypenoside Ⅲ) is part of a class of steroid glycosides; may have properties that inhibit or prevent the growth of tumors.

Ginsenoside Rb1

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Purity: 99.76%

Catalog No. T2822Alias Gypenoside III, Gypenoside ⅢCas No. 41753-43-9

Ginsenoside Rb1 (Gypenoside Ⅲ) is part of a class of steroid glycosides; may have properties that inhibit or prevent the growth of tumors.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$39	In Stock	In Stock
10 mg	$64	In Stock	In Stock
25 mg	$122	In Stock	In Stock
50 mg	$198	In Stock	In Stock
100 mg	$328	In Stock	In Stock
500 mg	$788	-	In Stock
1 mL x 10 mM (in DMSO)	$79	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.76%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Ginsenoside Rb1 AI Summary

Ginsenoside Rb1 demonstrates multifaceted bioactivity across various biological systems. It exhibits significant hepatoprotective activity in mouse hepatocytes by increasing cell survival rates and inhibiting D-galactosamine/TNFalpha-induced cell death in a dose-dependent manner. Additionally, it inhibits D-galactosamine/LPS-induced liver injury in ddY mice, reducing serum alanine transaminase levels by 331.0% and serum aspartate transaminase levels by 40.0% at 100 mg/kg. The compound shows strong antioxidant properties, inhibiting hydroxyl radical production with activity levels of 47.0% at 0.05% concentration and maintaining 42.0% activity post-heat processing. It also reduces superoxide anion generation in human neutrophils by 10.8% and inhibits neutrophil degranulation by 7.36% at 30 uM. Moreover, it inhibits AAPH-induced hemolysis in human erythrocytes with an IC50 of 3180.0 nM. In cellular assays, Ginsenoside Rb1 promotes neurite outgrowth in human SK-N-SH cells, showing 178.0% activity and increased vericosite numbers at 100 uM. It demonstrates cytotoxic effects on various cells, including a 91% reduction in viability of neonatal Human Dermal Fibroblasts (HDF) and 4.67% viability in mouse B16 cells at high concentrations. The compound also inhibits proliferation in human U251 cells and rat C6 cells with activity levels of 76.08% and 78.99% respectively at 100 uM. Ginsenoside Rb1 is effective as an HIV1 Reverse Transcriptase inhibitor with an IC50 greater than 200.0 ug/mL and inhibits the R132H mutant form of human IDH1 in Escherichia coli BL21 cells. It activates recombinant AMPKalpha2beta1gamma1 in the presence of CaMKKbeta with an EC50 of 16.8 nM. Finally, Ginsenoside Rb1 shows no significant inhibition of human DNA topoisomerase 1 and 2 activities, highlighting its selective bioactivity profile..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Ginsenoside Rb1 (Gypenoside Ⅲ) is part of a class of steroid glycosides; may have properties that inhibit or prevent the growth of tumors.
Targets&IC50	K+-ATPase:6.3±1.0 μM, Na+-ATPase:6.3±1.0 μM
Synonyms	Gypenoside III, Gypenoside Ⅲ

Chemical Properties

Molecular Weight	1109.29
Formula	C₅₄H₉₂O₂₃
Cas No.	41753-43-9
Smiles	CC(C)=CCC[C@](C)(O[C@@H]1O[C@H](CO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](O)[C@H](O)[C@H]1O)[C@H]1CC[C@]2(C)[C@@H]1[C@H](O)C[C@@H]1[C@@]3(C)CC[C@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)C(C)(C)[C@@H]3CC[C@@]21C
Relative Density.	1.0971 g/cm3 (Estimated)

Storage & Solubility Information

Storage

keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 145 mg/mL (130.71 mM), Sonication is recommended.

H2O: 100 mg/mL (90.15 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (3.61 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	0.9015 mL	4.5074 mL	9.0148 mL	45.0739 mL
5 mM	0.1803 mL	0.9015 mL	1.8030 mL	9.0148 mL
10 mM	0.0901 mL	0.4507 mL	0.9015 mL	4.5074 mL
20 mM	0.0451 mL	0.2254 mL	0.4507 mL	2.2537 mL
50 mM	0.0180 mL	0.0901 mL	0.1803 mL	0.9015 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0090 mL	0.0451 mL	0.0901 mL	0.4507 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc