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Sonlicromanol hydrochloride

Name: Sonlicromanol hydrochloride
Brand: TargetMol
SKU: T38013
Price: 95 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T38013Cas No. 2162149-24-6

Alias KH 176 hydrochloride

Sonlicromanol hydrochloride (KH176 hydrochloride) is a ROS-redox modulator that crosses the blood-brain barrier, has potential anticancer activity, improves m.3243A>G heterogeneity in iPSC-derived neurons associated with It has potential anticancer activity, ameliorates neuronal network dysfunction and transcriptomic changes associated with m.3243A>G heterogeneity in iPSC-derived neurons, and can be used for the treatment of mitochondrial diseases.

Sonlicromanol hydrochloride

🥰Excellent

Purity: 99.53%

Catalog No. T38013Alias KH 176 hydrochlorideCas No. 2162149-24-6

Pack Size	Price	Availability
1 mg	$95	In Stock
2 mg	$138	In Stock
5 mg	$238	In Stock
10 mg	$397	In Stock
25 mg	$816	In Stock
50 mg	$1,180	In Stock
100 mg	$1,500	In Stock
200 mg	$1,980	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.53%

ee:100%

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COA CSFC HNMR LCMS

Product Introduction

Bioactivity

Description	Sonlicromanol hydrochloride (KH176 hydrochloride) is a ROS-redox modulator that crosses the blood-brain barrier, has potential anticancer activity, improves m.3243A>G heterogeneity in iPSC-derived neurons associated with It has potential anticancer activity, ameliorates neuronal network dysfunction and transcriptomic changes associated with m.3243A>G heterogeneity in iPSC-derived neurons, and can be used for the treatment of mitochondrial diseases.
In vivo	In Ndufs4−/− mice (Leigh Disease model), Sonlicromanol hydrochloride (10 mg/kg; intraperitoneal injection, once daily) significantly improved rotarod and gait performance, reduced degeneration of retinal ganglion cells. Additionally, it resulted in significantly higher FA values in the external capsule and showed a similar trend in the cerebral peduncle[1].
Synonyms	KH 176 hydrochloride

Chemical Properties

Molecular Weight	368.9
Formula	C₁₉H₂₉ClN₂O₃
Cas No.	2162149-24-6
Smiles	Cl.Cc1c(C)c2O[C@@](C)(CCc2c(C)c1O)C(=O)N[C@@H]1CCCNC1
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store under nitrogen,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (406.61 mM), Sonification is recommended.

H2O: 80 mg/mL (216.86 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (13.55 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7108 mL	13.5538 mL	27.1076 mL	135.5381 mL
5 mM	0.5422 mL	2.7108 mL	5.4215 mL	27.1076 mL
10 mM	0.2711 mL	1.3554 mL	2.7108 mL	13.5538 mL
20 mM	0.1355 mL	0.6777 mL	1.3554 mL	6.7769 mL
50 mM	0.0542 mL	0.2711 mL	0.5422 mL	2.7108 mL
100 mM	0.0271 mL	0.1355 mL	0.2711 mL	1.3554 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc