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NRG1 alpha Protein, Human, Recombinant (EGF Domain, hFc)
(Synonyms: SMDF, NRG1-IT2, NRG1 α, neuregulin 1, NDF, MSTP131, MST131, HRGA, HRG1, HRG, HGL, GGF2, GGF, ARIA) Copy Product InfoSynonyms: SMDF, NRG1-IT2, NRG1 α, neuregulin 1, NDF, MSTP131, MST131, HRGA, HRG1, HRG, HGL, GGF2, GGF, ARIA
Catalog No. TMPY-02719 Copy Product Info
NRG1 alpha Protein, Human, Recombinant (EGF Domain, hFc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 35.8 kDa and the accession number is Q02297-1.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 µg | $55 | - | In Stock | |
| 10 µg | $87 | - | In Stock | |
| 20 µg | $142 | - | In Stock | |
| 50 µg | $277 | 7-10 days | 7-10 days | |
| 100 µg | $535 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:> 97 % as determined by SDS-PAGE
Appearance:Lyophilized powder
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | 1. Measured by its ability to biotinylated Human ErbB4-Fc in functional Elisa.
2. Measured by its ability to biotinylated Rhesus ErbB3 in functional Elisa. |
| Description | NRG1 alpha Protein, Human, Recombinant (EGF Domain, hFc) is expressed in HEK293 mammalian cells with Fc tag. The predicted molecular weight is 35.8 kDa and the accession number is Q02297-1. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | N-hFc |
| Accession Number | Q02297-1 |
| Construction | A DNA sequence encoding the human NRG1 isoform alpha (Q02297-1) EGF-like domain (Ser 177-Lys 241) was fused with the Fc region of human IgG1 at the N-terminus. Predicted N terminal: Glu |
| Protein Purity | > 97 % as determined by SDS-PAGE |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
| Reconstitution | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
| Synonyms | SMDF, NRG1-IT2, NRG1 α, neuregulin 1, NDF, MSTP131, MST131, HRGA, HRG1, HRG, HGL, GGF2, GGF, ARIA |
| Research Background | Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by the usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis. |
| Molecular Weight | 35.8 kDa (predicted); 38 kDa (reducing conditions) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Related Tags: NRG1 alpha Protein, Human, Recombinant (EGF Domain, hFc) chemical structure | NRG1 alpha Protein, Human, Recombinant (EGF Domain, hFc) molecular weight
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