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Aminopeptidase-IN-1

Name: Aminopeptidase-IN-1
Brand: TargetMol
SKU: T61278
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T61278Cas No. 374102-08-6

Aminopeptidase-IN-1 is a potent inhibitor of insulin-regulated aminopeptidase (IRAP) (Ki: 7.7 μM).Aminopeptidase-IN-1 can be used in studies of cognitive and memory disorders.

Aminopeptidase-IN-1

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Purity: 98.34%

Catalog No. T61278Cas No. 374102-08-6

Aminopeptidase-IN-1 is a potent inhibitor of insulin-regulated aminopeptidase (IRAP) (Ki: 7.7 μM).Aminopeptidase-IN-1 can be used in studies of cognitive and memory disorders.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$39	-	In Stock
10 mg	$55	-	In Stock
25 mg	$105	-	In Stock
50 mg	$163	-	In Stock
100 mg	$243	-	In Stock
500 mg	$588	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.34%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Aminopeptidase-IN-1 AI Summary

Aminopeptidase-IN-1 shows bioactivity in various assays, including inhibiting Tau fibril formation by binding to tau fibrils in assays utilizing fluorescence polarization and Thioflavin T binding. It demonstrates cytotoxic effects on NIH3T3 cells as shown in the Luminescence Cell-Based Dose Response HTS assay and inhibits ROR gamma transcriptional activity. Additionally, Aminopeptidase-IN-1 inhibits enzymes such as aldehyde dehydrogenase 1, Sfp phosphopantetheinyl transferase, and JMJD2A-Tudor Domain, modulates lipid storage in Drosophila S3 cells, and inhibits Trypanosoma cruzi replication. It also acts on the ERK signaling pathway and histone lysine methyltransferase G9a, and serves as an antagonist for the Neuropeptide S receptor and BAZ2B. Moreover, it induces synthetic lethality in tumor cells producing 2HG in specific cell lines, inhibits MBNL1-poly(CUG) RNA binding, and induces DNA re-replication in normal breast cells. Aminopeptidase-IN-1 has antiviral activity against Foot and Mouth Disease Virus and inhibits IRAP in HEKT cells, with a Ki value of 7700 nM, as assessed by the hydrolysis of L-leucine-4-methyl-7-coumarinylamide after 30 minutes. These findings suggest that Aminopeptidase-IN-1 exhibits a diverse range of bioactivities, including anti-tau fibrillation, cytotoxicity, enzyme inhibition, and antiviral properties..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Aminopeptidase-IN-1 is a potent inhibitor of insulin-regulated aminopeptidase (IRAP) (Ki: 7.7 μM).Aminopeptidase-IN-1 can be used in studies of cognitive and memory disorders.
Targets&IC50	IRAP:7.7 μM(Ki)

Chemical Properties

Molecular Weight	356.33
Formula	C₁₈H₁₆N₂O₆
Cas No.	374102-08-6
Smiles	CCOC(=O)C1=C(N)Oc2cc(O)ccc2C1c1ccc(cc1)[N+]([O-])=O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (168.38 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.61 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8064 mL	14.0319 mL	28.0639 mL	140.3194 mL
5 mM	0.5613 mL	2.8064 mL	5.6128 mL	28.0639 mL
10 mM	0.2806 mL	1.4032 mL	2.8064 mL	14.0319 mL
20 mM	0.1403 mL	0.7016 mL	1.4032 mL	7.0160 mL
50 mM	0.0561 mL	0.2806 mL	0.5613 mL	2.8064 mL
100 mM	0.0281 mL	0.1403 mL	0.2806 mL	1.4032 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc