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Anti-Phospho-IRF3 (Ser386) Antibody (7A218)
😃Good
Catalog No. TMAH-00912
Alias p-IRF3 (Ser386), p-IRF3 (S386), Phospho-IRF3 (S386), MGC94729, IRF3 (p-Ser386), IRF3 (p-S386), IRF 3, Interferon regulatory factor 3, IIAE7
Anti-Phospho-IRF3 (Ser386) Antibody (7A218) is an antibody targeting Phospho-IRF3 (Ser386). Anti-Phospho-IRF3 (Ser386) Antibody (7A218) can be used in ELISA,WB.
Anti-Phospho-IRF3 (Ser386) Antibody (7A218)
Anti-Phospho-IRF3 (Ser386) Antibody (7A218)
😃Good
Catalog No. TMAH-00912Alias p-IRF3 (Ser386), p-IRF3 (S386), Phospho-IRF3 (S386), MGC94729, IRF3 (p-Ser386), IRF3 (p-S386), IRF 3, Interferon regulatory factor 3, IIAE7
Anti-Phospho-IRF3 (Ser386) Antibody (7A218) is an antibody targeting Phospho-IRF3 (Ser386). Anti-Phospho-IRF3 (Ser386) Antibody (7A218) can be used in ELISA,WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $209 | 7-10 days | 7-10 days | |
| 100 μL | $349 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Phospho-IRF3 (Ser386) Antibody (7A218) is an antibody targeting Phospho-IRF3 (Ser386). Anti-Phospho-IRF3 (Ser386) Antibody (7A218) can be used in ELISA,WB. |
| Synonyms | p-IRF3 (Ser386), p-IRF3 (S386), Phospho-IRF3 (S386), MGC94729, IRF3 (p-Ser386), IRF3 (p-S386), IRF 3, Interferon regulatory factor 3, IIAE7 |
| Ig Type | Rabbit IgG |
| Clone | 7A218 |
| Reactivity | Human |
| Verified Activity | Western Blot -Positive WB detected in Hela whole cell lysate(treated with Calyculin A or not) -All lanes Phospho-IRF3 antibody at 1.03μg/ml -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 47 KDa -Observed band size: 47 KDa |
| Application | |
| Recommended Dose | WB:1:500-1:5000. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cytoplasm. Nucleus. Mitochondrion. |
| Tissue Specificity | Expressed constitutively in a variety of tissues. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages. In response to Sendai virus infection, is recruited by TOMM70:HSP90AA1 to mitochondrion and forms an apoptosis complex TOMM70:HSP90AA1:IRF3:BAX inducing apoptosis. Key transcription factor regulating the IFN response during SARS-CoV-2 infection. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human Phospho-IRF3 (S386) |
| Antigen Species | Human |
| Gene Name | IRF3 |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Immunology |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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