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pan-KRAS-IN-16
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Catalog No. T9184Cas No. 2368246-78-8
3344 is an inhibitor of KRAS-effector interactions,with an affnity of 126nm.
pan-KRAS-IN-16
😃Good
Catalog No. T9184Cas No. 2368246-78-8
3344 is an inhibitor of KRAS-effector interactions,with an affnity of 126nm.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $929 | 1-2 weeks | 1-2 weeks | |
| 50 mg | $1,207 | 1-2 weeks | 1-2 weeks | |
| 100 mg | $1,810 | 1-2 weeks | 1-2 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | 3344 is an inhibitor of KRAS-effector interactions,with an affnity of 126nm. |
| In vitro | In vitro competition studies of 3344 binding to KRAS-G12V in waterLOGSY NMR show the anti-RAS scFv inhibits 3344 binding to KRAS. In view of the in vitro inhibition by the anti-RAS scFv of 3344 binding to RASand because the iDAb RAS interferes with BRET signal in cells, 3344 was used for valida?tion of the BRET2 toolbox for RAS-effector PPI inhibitors. |
| Molecular Weight | 390.47 |
| Formula | C24H26N2O3 |
| Cas No. | 2368246-78-8 |
| Relative Density. | 1.182 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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