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Molindone (Synonyms: SPN-810M, Molindonum, Moban, (±)-Molindone)

Name: Molindone
Brand: TargetMol
SKU: T21432
Price: 210 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T21432 Copy Product Info

Purity: 99.67%

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Molindone ((±)-Molindone) is a therapeutic antipsychotic used to treat schizophrenia by blocking the action of dopamine in the brain. molindone is often used in combination with serotonin in a dose-dependent manner to increase errors and decrease response rates.

Molindone

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Catalog No. T21432

Synonyms SPN-810M, Molindonum, Moban, (±)-Molindone

Cas No. 7416-34-4

Pack Size	Price	USA Stock	Global Stock
1 mg	$210	In Stock	In Stock
5 mg	$497	In Stock	In Stock
10 mg	$678	In Stock	In Stock
25 mg	$953	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.67%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Molindone ((±)-Molindone) is a therapeutic antipsychotic used to treat schizophrenia by blocking the action of dopamine in the brain. molindone is often used in combination with serotonin in a dose-dependent manner to increase errors and decrease response rates.
In vivo	Molindone (1 to 10 mg/kg ; subcutaneous injection ; rat) produced a reduction in striatal p-tyramine, an increase in m-tyramine and an increase in dopamine turnover.[5] Molindone (100 mg/kg ; subcutaneous injection ; rat) the effects on both tyramines and on dopamine metabolism were reversed. These results can be interpreted as molindone acting as a partial agonist.[5] The concentrations of hypothalamic p- and m-octopamine were increased by the higher doses of molindone (20 to 100 mg/kg ; subcutaneous injection ; rat) employed while lower doses produced no significant effects.[5]
Synonyms	SPN-810M, Molindonum, Moban, (±)-Molindone

Chemical Properties

Molecular Weight	276.37
Formula	C₁₆H₂₄N₂O₂
Cas No.	7416-34-4
Smiles	C(C)C=1C2=C(NC1C)CCC(CN3CCOCC3)C2=O
Relative Density.	1.140 g/cm3 (Predicted)

Storage & Solubility Information

Storage

02 | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: Insoluble

DMSO: 60 mg/mL (217.1 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6183 mL	18.0917 mL	36.1834 mL	180.9169 mL
5 mM	0.7237 mL	3.6183 mL	7.2367 mL	36.1834 mL
10 mM	0.3618 mL	1.8092 mL	3.6183 mL	18.0917 mL
20 mM	0.1809 mL	0.9046 mL	1.8092 mL	9.0458 mL
50 mM	0.0724 mL	0.3618 mL	0.7237 mL	3.6183 mL
100 mM	0.0362 mL	0.1809 mL	0.3618 mL	1.8092 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc