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CDK2/PIM1-IN-1

Name: CDK2/PIM1-IN-1
Brand: TargetMol
SKU: T206369
Rating: 4.5 (1 reviews)

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Catalog No. T206369

CDK2/PIM1-IN-1 is an inhibitor of the kinases CDK2 (IC50: 0.27 μM) and PIM1 (IC50: 0.67 μM). It can induce apoptosis (cell death) and reduce the expression of TNF-α, which promotes tumors. CDK2/PIM1-IN-1 exhibits antitumor activity.

CDK2/PIM1-IN-1

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Catalog No. T206369

Pack Size	Price	Availability	Quantity
10 mg	Inquiry	Backorder
50 mg	Inquiry	Backorder

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	CDK2/PIM1-IN-1 is an inhibitor of the kinases CDK2 (IC50: 0.27 μM) and PIM1 (IC50: 0.67 μM). It can induce apoptosis (cell death) and reduce the expression of TNF-α, which promotes tumors. CDK2/PIM1-IN-1 exhibits antitumor activity.
Targets&IC50	CDK2:0.27 μM
In vitro	CDK2/PIM1-IN-1 (Compound 6b) exhibits antiproliferative effects on MCF7 (IC50: 5.54 μM), HCT-116 (IC50: 2.62 μM), HepG2 (IC50: 3.99 μM), and HeLa cell lines (IC50: 8.31 μM), with moderate safety in normal breast cell line MCF-10A (IC50: 39.44 μM). In HCT116 cells, CDK2/PIM1-IN-1 (24 hours) inhibits the G0-G1 phase (%G0-G1: 83.43%) and induces significant early (8.28%) and late (20.09%) apoptosis. It also inhibits CDK (IC50: 0.27 μM) and PIM1 (IC50: 0.67 μM) within the HCT116 cell line.
In vivo	CDK2/PIM1-IN-1 (Compound 6b), administered at 10 mg/kg intraperitoneally three times a week for two weeks, effectively reduces tumor volume by 71.42% and tumor weight by 70.58% in a solid Ehrlich carcinoma (SEC) mouse model while demonstrating good tolerability.

Chemical Properties

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc