Shopping Cart

Your shopping cart is currently empty

EGNHS

Name: EGNHS
Brand: TargetMol
SKU: T15203
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

😃Good

Catalog No. T15203Cas No. 70539-42-3

Alias EGS crosslinker

EGNHS (EGS crosslinker) is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

EGNHS

😃Good

Purity: 99.83%

Catalog No. T15203Alias EGS crosslinkerCas No. 70539-42-3

EGNHS (EGS crosslinker) is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$41	-	In Stock
100 mg	$66	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.83%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	EGNHS (EGS crosslinker) is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
In vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Synonyms	EGS crosslinker

Chemical Properties

Molecular Weight	456.36
Formula	C₁₈H₂₀N₂O₁₂
Cas No.	70539-42-3
Smiles	O=C(CCC(OCCOC(CCC(ON1C(CCC1=O)=O)=O)=O)=O)ON2C(CCC2=O)=O
Relative Density.	1.52g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (197.21 mM), Sonication is recommended.

H2O: 3.8 mg/mL (8.33 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (7.23 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1913 mL	10.9563 mL	21.9125 mL	109.5626 mL
5 mM	0.4383 mL	2.1913 mL	4.3825 mL	21.9125 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.2191 mL	1.0956 mL	2.1913 mL	10.9563 mL
20 mM	0.1096 mL	0.5478 mL	1.0956 mL	5.4781 mL
50 mM	0.0438 mL	0.2191 mL	0.4383 mL	2.1913 mL
100 mM	0.0219 mL	0.1096 mL	0.2191 mL	1.0956 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc