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Mer/c-Met-IN-1
Catalog No. T213368 Copy Product Info
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Mer/c-Met-IN-1 is a potent dual inhibitor of Mer and c-Met, with IC50 values of 1 nM and 19 nM, respectively. It effectively inhibits the proliferation and migration of cancer cells and induces apoptosis (apoptosis). This compound is applicable in cancer research, including studies on colon cancer.
Mer/c-Met-IN-1
Copy Product Info🥰Excellent
Catalog No. T213368
Mer/c-Met-IN-1 is a potent dual inhibitor of Mer and c-Met, with IC50 values of 1 nM and 19 nM, respectively. It effectively inhibits the proliferation and migration of cancer cells and induces apoptosis (apoptosis). This compound is applicable in cancer research, including studies on colon cancer.
Mer/c-Met-IN-1
Cas No. 3062159-91-2
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Mer/c-Met-IN-1 is a potent dual inhibitor of Mer and c-Met, with IC50 values of 1 nM and 19 nM, respectively. It effectively inhibits the proliferation and migration of cancer cells and induces apoptosis (apoptosis). This compound is applicable in cancer research, including studies on colon cancer. |
| In vitro | Mer/c-Met-IN-1 demonstrates significant antiproliferative effects on HCT116, A2780, and PC-3 cancer cells, with IC50 values of 1.01 μM, 0.96 μM, and 3.42 μM, respectively. In human liver microsomes, it shows good metabolic stability, with a half-life of 72.6 minutes and a clearance rate of 0.05 mL/min/mg. The compound exhibits weak inhibition of the hERG potassium channel, with an IC50 value greater than 40 μM. Additionally, Mer/c-Met-IN-1 induces apoptosis in HCT116 cells dose-dependently at concentrations of 0.4-3.2 μM over 48 hours, with an ED50 of 1.368 pM. It also significantly inhibits the migration of HCT116 cells at concentrations ranging from 0.8 to 20 μM over 24 hours. |
| Molecular Weight | 675.77 |
| Formula | C38H38FN7O4 |
| Cas No. | 3062159-91-2 |
| Smiles | O=C(NC1=CC=C(OC2=NC(=NC=C2)NC3=CC=CC(=C3)N4CCN(C)CC4)C=C1)C5=CN(C=C(C5=O)C=6C=CC(F)=CC6)CC7OCCC7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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