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Selective PI3Kδ Inhibitor 1

Name: Selective PI3Kδ Inhibitor 1
Brand: TargetMol
SKU: T5831
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5831Cas No. 2088525-31-7

Selective PI3Kδ Inhibitor 1 is a PI3Kδ Inhibitor( IC50 = 0.9 nM).

Selective PI3Kδ Inhibitor 1

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Purity: 97.96%

Catalog No. T5831Cas No. 2088525-31-7

Selective PI3Kδ Inhibitor 1 is a PI3Kδ Inhibitor( IC50 = 0.9 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$32	In Stock	In Stock
5 mg	$95	In Stock	In Stock
10 mg	$143	In Stock	In Stock
25 mg	$235	In Stock	In Stock
50 mg	$321	In Stock	In Stock
100 mg	$439	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.96%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Selective PI3Kδ Inhibitor 1 AI Summary

Selective PI3Kδ Inhibitor 1 exhibits potent bioactivity in inhibiting PI3K isoforms, with the lowest IC50 observed for PI3K p110delta/p85alpha, specifically PI3Kdelta, with an IC50 value of 0.8 nM. It shows high selectivity ratios for PI3Kalpha and PI3Kbeta compared to PI3Kdelta. The compound also inhibits DYRK1A, DYRK1B, and CSNK1G3, and demonstrates inhibitory effects on AKT phosphorylation and the 5HT1A receptor, along with moderate selectivity towards ERG. Additionally, it exhibits cytotoxicity against human JeKo1 cells with an IC50 value of 120.0 nM. Selective PI3Kδ Inhibitor 1 has good solubility, low clearance, favorable oral bioavailability in rats, and properties indicating potential for effective drug delivery and distribution, such as favorable lipophilicity, volume of distribution, and efflux characteristics..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Selective PI3Kδ Inhibitor 1 is a PI3Kδ Inhibitor( IC50 = 0.9 nM).
Targets&IC50	PI3Kδ:0.9 nM

Chemical Properties

Molecular Weight	429.45
Formula	C₂₃H₂₀FN₇O
Cas No.	2088525-31-7
Smiles	CN1C(C2(CC2)C3=CC=CC=C3)=NC(=N1)C4=NC(=C(N)N=C4)C5=CC(F)=C(C(N)=O)C=C5
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 43 mg/mL (100.13 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3286 mL	11.6428 mL	23.2856 mL	116.4280 mL
5 mM	0.4657 mL	2.3286 mL	4.6571 mL	23.2856 mL
10 mM	0.2329 mL	1.1643 mL	2.3286 mL	11.6428 mL
20 mM	0.1164 mL	0.5821 mL	1.1643 mL	5.8214 mL
50 mM	0.0466 mL	0.2329 mL	0.4657 mL	2.3286 mL
100 mM	0.0233 mL	0.1164 mL	0.2329 mL	1.1643 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc