YM-58790 hydrochloride

Name: YM-58790 hydrochloride
Brand: TargetMol
SKU: T13372
Rating: 4.5 (1 reviews)

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Catalog No. T13372Cas No. 214558-72-2

YM-58790 is a potent M3 muscarinic receptor antagonist(Ki of 15 nM).

YM-58790 hydrochloride

😃Good

Catalog No. T13372Cas No. 214558-72-2

YM-58790 is a potent M3 muscarinic receptor antagonist(Ki of 15 nM).

Pack Size	Price	Availability
5 mg	$324	7-10 days
50 mg	$1,670	7-10 days
100 mg	$2,690	7-10 days

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Product Introduction

Bioactivity

Description	YM-58790 is a potent M3 muscarinic receptor antagonist(Ki of 15 nM).
Targets&IC50	M3 mAChR:15 nM (Ki), M2 mAChR:260 nM (Ki), M1 mAChR:28 nM (Ki)
In vitro	In vitro, YM-58790 exhibits selective antagonism between urinary bladder contraction and salivary secretion .
In vivo	In pithed rats, The effect of YM-58790 on McN-A343-induced pressor, as an indication of M1 antagonism in vivo, is much less potent than bladder contraction. YM-58790 exhibits potent inhibitory activity on bladder pressuer in reflexly-evoked rhythmic contraction, similar to oxybutynin, and has appr ten times less inhibitory effect on oxotremorine-induced salivary secretion than oxybutynin in rats.

Chemical Properties

Molecular Weight	466.02
Formula	C₂₇H₃₂ClN₃O₂
Cas No.	214558-72-2
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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