YM-58790 hydrochloride

Name: YM-58790 hydrochloride
Brand: TargetMol
SKU: T13372
Rating: 4.5 (1 reviews)

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Catalog No. T13372Cas No. 214558-72-2

YM-58790 is a potent M3 muscarinic receptor antagonist(Ki of 15 nM).

YM-58790 hydrochloride

😃Good

Catalog No. T13372Cas No. 214558-72-2

YM-58790 is a potent M3 muscarinic receptor antagonist(Ki of 15 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$324	7-10 days	7-10 days
50 mg	$1,670	7-10 days	7-10 days
100 mg	$2,690	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	YM-58790 is a potent M3 muscarinic receptor antagonist(Ki of 15 nM).
Targets&IC50	M1 mAChR:28 nM (Ki), M2 mAChR:260 nM (Ki), M3 mAChR:15 nM (Ki)
In vitro	In vitro, YM-58790 exhibits selective antagonism between urinary bladder contraction and salivary secretion .
In vivo	In pithed rats, The effect of YM-58790 on McN-A343-induced pressor, as an indication of M1 antagonism in vivo, is much less potent than bladder contraction. YM-58790 exhibits potent inhibitory activity on bladder pressuer in reflexly-evoked rhythmic contraction, similar to oxybutynin, and has appr ten times less inhibitory effect on oxotremorine-induced salivary secretion than oxybutynin in rats.

Chemical Properties

Molecular Weight	466.02
Formula	C₂₇H₃₂ClN₃O₂
Cas No.	214558-72-2
Smiles	Cl.CNc1ccc(CN2CCC(CC2)OC(=O)NC(c2ccccc2)c2ccccc2)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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