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CDK7-IN-27
🥰Excellent
Catalog No. T209449
CDK7-IN-27 (Compound 37) is a selective inhibitor of cyclin-dependent kinase 7 (CDK7), with a Ki value of 3 nM. It effectively causes cell cycle arrest at the G0/G1 phase.
CDK7-IN-27
CDK7-IN-27
🥰Excellent
Catalog No. T209449
CDK7-IN-27 (Compound 37) is a selective inhibitor of cyclin-dependent kinase 7 (CDK7), with a Ki value of 3 nM. It effectively causes cell cycle arrest at the G0/G1 phase.
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Product Introduction
Bioactivity
Chemical Properties
| Description | CDK7-IN-27 (Compound 37) is a selective inhibitor of cyclin-dependent kinase 7 (CDK7), with a Ki value of 3 nM. It effectively causes cell cycle arrest at the G0/G1 phase. |
| Targets&IC50 | CDK7:3 nM, CDK2:19.4 nM |
| In vitro | CDK7-IN-27 effectively inhibits the proliferation of MDA-MB-453 cells with an EC50 of 1.49 μM when used in concentrations ranging from 0.04 to 10 μM over the course of 5 days. At a concentration of 1 μM over 24 hours, CDK7-IN-27 demonstrates good metabolic stability in both mouse and human liver microsomes, with half-life periods of 38.5 minutes and 34.1 minutes, respectively. Additionally, CDK7-IN-27 (0-1 μM, 24 h) arrests the cell cycle in the G0/G1 phase by inhibiting the phosphorylation of retinoblastoma protein through CDK7 inhibition. |
| Formula | C26H37N7O2 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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