Shopping Cart

Your shopping cart is currently empty

(S,R,S)-AHPC-PEG3-N3

Name: (S,R,S)-AHPC-PEG3-N3
Brand: TargetMol
SKU: T17909
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T17909Cas No. 1797406-80-4

Alias VHL Ligand-Linker Conjugates 8, VH032-PEG3-N3, E3 ligase Ligand-Linker Conjugates 12

(S, R, S)-AHPC-PEG3-N3 (VHL Ligand-Linker Conjugates 8) is a synthesized E3 ligase ligand-linker conjugate. (S, R, S)-AHPC-PEG3-N3 incorporates the (S, R, S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology.

(S,R,S)-AHPC-PEG3-N3

🥰Excellent

Purity: 98.83%

Catalog No. T17909Alias VHL Ligand-Linker Conjugates 8, VH032-PEG3-N3, E3 ligase Ligand-Linker Conjugates 12Cas No. 1797406-80-4

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$47	In Stock	In Stock
10 mg	$71	In Stock	In Stock
25 mg	$123	In Stock	In Stock
50 mg	$179	In Stock	In Stock
100 mg	$255	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:98.83%

Color:Yellow

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	(S, R, S)-AHPC-PEG3-N3 (VHL Ligand-Linker Conjugates 8) is a synthesized E3 ligase ligand-linker conjugate. (S, R, S)-AHPC-PEG3-N3 incorporates the (S, R, S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology.
In vitro	(S,R,S)-AHPC-PEG3-N3 is derived from patent WO/2016/146985A1, figure 11. PROTAC features an A-L-B structure that tethers a bromodomain inhibitor, binding a BET family protein, to a small molecule E3 ubiquitin ligase protein binding ligand via a suitable linker[1][2].
Synonyms	VHL Ligand-Linker Conjugates 8, VH032-PEG3-N3, E3 ligase Ligand-Linker Conjugates 12

Chemical Properties

Molecular Weight	645.77
Formula	C₃₀H₄₃N₇O₇S
Cas No.	1797406-80-4
Smiles	C([C@@H](NC(COCCOCCOCCN=[N+]=[N-])=O)[C@](C)(C)C)(=O)N1[C@H](C(NCC2=CC=C(C=C2)C=3SC=NC3C)=O)C[C@@H](O)C1
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (387.13 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5485 mL	7.7427 mL	15.4854 mL	77.4269 mL
5 mM	0.3097 mL	1.5485 mL	3.0971 mL	15.4854 mL
10 mM	0.1549 mL	0.7743 mL	1.5485 mL	7.7427 mL
20 mM	0.0774 mL	0.3871 mL	0.7743 mL	3.8713 mL
50 mM	0.0310 mL	0.1549 mL	0.3097 mL	1.5485 mL
100 mM	0.0155 mL	0.0774 mL	0.1549 mL	0.7743 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc