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Orticumab
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Catalog No. T77123Cas No. 1314241-10-5
Alias MLDL1278A
Orticumab (MLDL1278A) is a recombinant human monoclonal antibody engineered to specifically bind to epitopes on oxidized low-density lipoprotein (oxLDL). it demonstrates therapeutic potential by modulating autoimmune responses against oxLDL, thereby improving atherosclerotic plaque pathology, and also shows significant promise for the treatment of autoimmune inflammatory conditions such as psoriasis.
Orticumab
Orticumab
😃Good
Catalog No. T77123Alias MLDL1278ACas No. 1314241-10-5
Orticumab (MLDL1278A) is a recombinant human monoclonal antibody engineered to specifically bind to epitopes on oxidized low-density lipoprotein (oxLDL). it demonstrates therapeutic potential by modulating autoimmune responses against oxLDL, thereby improving atherosclerotic plaque pathology, and also shows significant promise for the treatment of autoimmune inflammatory conditions such as psoriasis.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $413 | - | In Stock | |
| 5 mg | $1,230 | - | In Stock | |
| 10 mg | $1,990 | - | In Stock | |
| 25 mg | $2,950 | - | In Stock | |
| 50 mg | $3,980 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:≥95% (SDS-PAGE); 98.56% (SEC-HPLC)
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| Description | Orticumab (MLDL1278A) is a recombinant human monoclonal antibody engineered to specifically bind to epitopes on oxidized low-density lipoprotein (oxLDL). it demonstrates therapeutic potential by modulating autoimmune responses against oxLDL, thereby improving atherosclerotic plaque pathology, and also shows significant promise for the treatment of autoimmune inflammatory conditions such as psoriasis. |
| In vivo | Methods: Orticumab (10 mg/kg, intraperitoneal injection, once a week for three weeks) was used to treat B6.lpr.ApoE-/- mice (18 weeks old) fed a high-fat diet (HFD) and its therapeutic effect was observed. Results: Orticumab treatment reduced aortic arch atherosclerosis by 42.8% and CD68 macrophage subvalvular plaque staining by 30.5%. [1] |
| Synonyms | MLDL1278A |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | oxLDL |
| Molecular Weight | ~150 kDa |
| Cas No. | 1314241-10-5 |
| Color | Transparent |
| Appearance | Liquid |
| Isotype | Human IgG1 lambda2 |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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