Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) is a mouse-derived inhibitory antibody that targets mouse 4-1BBL/CD137L and blocks 4-1BB ligand (4-1BBL), thereby inhibiting the activity of CD4+ and CD8+ T cells, and is suitable for research related to cancer, infection, inflammation and immunology, specifically applicable to models such as MC38 tumor, lymphocytic choriomeningitis virus (LCMV) infection, and herpetic stromal keratitis (HSK).

Treatment with Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) at concentrations of 5 μg/mL or 50 μg/mL for 3 days can inhibit the proliferation of CD4+ and CD8+ T cells in response to allogeneic antigen-presenting cells, and attenuate the cytotoxicity of normal C57BL/6 T cells against host allogeneic antigens after stimulation with Balb/c antigen-presenting cells [3].

Intraperitoneal injection of Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1) at a dose of 150 μg (administered 1 day before infection and on days 1 and 3 after infection), when combined with Anti-OX40L , can attenuate the magnitude of LCMV-specific CD8+ T cell responses in Cd70/80/86−/− mice infected with lymphocytic choriomeningitis virus (LCMV) [1].
Intraperitoneal injection of this antibody at a dose of 200 μg (administered on days 0, 3, 6, and 8) can inhibit the progression of herpetic stromal keratitis (HSK) in mice infected with herpes simplex virus type 1 strain RE [2].
When administered intraperitoneally at a dose of 200 μg (on days 0, 2, and 4), this antibody can prolong the survival of cardiac allografts following transplantation from Balb/c mice to C57BL/6 mice [3].
Intraperitoneal injection of this antibody at a dose of 100 μg per 25 g body weight (administered daily before IMQ application) can alleviate the inflammatory response in a mouse model of psoriasis induced by imiquimod (IMQ) [4].
Intraperitoneal injection of this antibody at a dose of 100 μg (administered on days 0 and 2), when combined with the 3H3 antibody, can effectively inhibit tumor growth in MC38 tumor-bearing mice [5].

TKS-1

Mouse

Monoclonal

Unconjugated