Immunoglobulin superfamily member 11(IGSF11) is expressed on the plasma membrane in the testis and brain. These IGSF proteins undergo final modifications during capacitation and/or the acrosome reaction. IGSF proteins share significant homology with endothelial cell-selective adhesion molecule and coxsackievirus and adenovirus receptor, which mediates cell attachment and homotypic intercellular interactions. In clinical, the IGSF11 has been reported to overexpressed in colorectal cancers and hepatocellular carcinomas, as well as intestinal-type gastric cancers, compared to their corresponding non-cancerous tissues. The IGSF11 has also been found expressed abundantly in the testis and ovary and the IGSF11 can be used as a candidate of cancer-testis antigen.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
20 μg | In stock | $ 178.00 | |
100 μg | 5 days | $ 660.00 | |
200 μg | 5 days | $ 1,120.00 | |
500 μg | 5 days | $ 2,270.00 |
Biological Information | Testing in progress |
Description | Immunoglobulin superfamily member 11(IGSF11) is expressed on the plasma membrane in the testis and brain. These IGSF proteins undergo final modifications during capacitation and/or the acrosome reaction. IGSF proteins share significant homology with endothelial cell-selective adhesion molecule and coxsackievirus and adenovirus receptor, which mediates cell attachment and homotypic intercellular interactions. In clinical, the IGSF11 has been reported to overexpressed in colorectal cancers and hepatocellular carcinomas, as well as intestinal-type gastric cancers, compared to their corresponding non-cancerous tissues. The IGSF11 has also been found expressed abundantly in the testis and ovary and the IGSF11 can be used as a candidate of cancer-testis antigen. |
Species | Human |
Expression System | HEK293 |
Tag | His |
Accession Number | AAH34411.1 |
Synonyms | CT119, immunoglobulin superfamily, member 11, BT-IgSF, Igsf13, CXADRL1, VSIG3 |
Construction | A DNA sequence encoding the extracellular domain of human IGSF11 (AAH34411.1) (Met 1-Gly 240) was fused with a polyhistidine tag at the C-terminus |
Protein Purity |
≥ 85 % as determined by SDS-PAGE. ≥ 85 % as determined by SEC-HPLC.
|
Molecular Weight | Approxiamtely 24.6 kDa |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
Formulation | Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0. 01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA. |
Reconstitution | A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information. |
Stability & Storage |
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Shipping |
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
Research Background | Immunoglobulin superfamily member 11(IGSF11) is expressed on the plasma membrane in the testis and brain. These IGSF proteins undergo final modifications during capacitation and/or the acrosome reaction. IGSF proteins share significant homology with endothelial cell-selective adhesion molecule and coxsackievirus and adenovirus receptor, which mediates cell attachment and homotypic intercellular interactions. In clinical, the IGSF11 has been reported to overexpressed in colorectal cancers and hepatocellular carcinomas, as well as intestinal-type gastric cancers, compared to their corresponding non-cancerous tissues. The IGSF11 has also been found expressed abundantly in the testis and ovary and the IGSF11 can be used as a candidate of cancer-testis antigen. |
bottom
Please read the User Guide of Recombinant Proteins for more specific information.
IGSF11 Protein, Human, Recombinant (His) VSIG-3 CXADRL-1 CT119 immunoglobulin superfamily, member 11 CT 119 BT-IgSF Igsf13 CXADRL1 VSIG3 CT-119 VSIG 3 CXADRL 1 recombinant recombinant-proteins proteins protein