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Eflornithine hydrochloride

Catalog No. T40789 CAS 68278-23-9

Synonyms: MDL71782hydrochloride, RMI71782hydrochloride, DFMO hydrochloride, α-difluoromethylornithinehydrochloride

Eflornithine hydrochloride, a specific and irreversible inhibitor of ornithine decarboxylase enzyme, is a medication used for the treatment of African trypanosomiasis and excessive facial hair growth in women.

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Eflornithine hydrochloride Chemical Structure

Eflornithine hydrochloride, CAS 68278-23-9

Pack Size	Availability	Price/USD	Quantity
10 mg	35 days	$ 240.00
50 mg	35 days	$ 984.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vivo

Eflornithine stands as the sole novel molecule registered in the past 50 years for treating human African trypanosomiasis, primarily serving as an alternative for cases resistant to melarsoprol involving Trypanosoma brucei gambiense[1]. Additionally, a 15% eflornithine cream has proven more effective than a placebo in reducing unwanted facial hair growth, showing significant improvement in 58% of users versus 34% of placebo recipients after six months[2]. When applied to microneedle-prepared skin in mice, eflornithine's hair growth inhibition is notably increased[3]. Furthermore, eflornithine treatment in hypertensive rats with coarctation has been shown to normalize responses to KCl, norepinephrine, and acetylcholine, illustrating a potential in restoring vascular function within 14 days[4].

Synonyms	MDL71782hydrochloride, RMI71782hydrochloride, DFMO hydrochloride, α-difluoromethylornithinehydrochloride
Molecular Weight	218.63
Formula	C6H13ClF2N2O2
CAS No.	68278-23-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Burri C, et al. Eflornithine for the treatment of human African trypanosomiasis. Parasitol Res. 2003 Jun;90 Supp 1:S49-52. 2. Balfour JA, et al. Topical eflornithine. Am J Clin Dermatol. 2001;2(3):197-201; discussion 202. 3. Kumar A, et al. A method to improve the efficacy of topical eflornithine hydrochloride cream. Drug Deliv. 2016 Jun;23(5):1495-501. 4. Lipke DW, et al. Eflornithine alters changes in vascular responsiveness associated with coarctation hypertension. Clin Exp Hypertens. 1997 Apr;19(3):297-312.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Eflornithine hydrochloride 68278-23-9 alpha-difluoromethylornithinehydrochloride DFMO Hydrochloride Eflornithine Hydrochloride MDL71782hydrochloride RMI71782hydrochloride DFMO hydrochloride a-difluoromethylornithinehydrochloride α-difluoromethylornithinehydrochloride inhibitor inhibit

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