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Nattokinase
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Catalog No. T38736Cas No. 133876-92-3
Alias Nattokinase (Natto fermentation)
Nattokinase is a serine protease derived from nattō, exhibiting oral bioavailability and fibrinolytic/anticoagulant properties. It degrades fibrin, fibrinolytic substrates, and PAI-1 to dissolve thrombi while inhibiting platelet aggregation, making it suitable for cardiovascular disease and Alzheimer's disease research.
Nattokinase
😃Good
Catalog No. T38736Alias Nattokinase (Natto fermentation)Cas No. 133876-92-3
Nattokinase is a serine protease derived from nattō, exhibiting oral bioavailability and fibrinolytic/anticoagulant properties. It degrades fibrin, fibrinolytic substrates, and PAI-1 to dissolve thrombi while inhibiting platelet aggregation, making it suitable for cardiovascular disease and Alzheimer's disease research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $32 | - | In Stock | |
| 5 mg | $73 | - | In Stock | |
| 10 mg | $123 | - | In Stock | |
| 25 mg | $215 | - | In Stock | |
| 50 mg | $328 | - | In Stock | |
| 100 mg | $562 | - | In Stock | |
| 200 mg | $783 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
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Potency:20000 FU/G
Appearance:Solid
Color:Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Nattokinase is a serine protease derived from nattō, exhibiting oral bioavailability and fibrinolytic/anticoagulant properties. It degrades fibrin, fibrinolytic substrates, and PAI-1 to dissolve thrombi while inhibiting platelet aggregation, making it suitable for cardiovascular disease and Alzheimer's disease research. |
| In vitro | After 8 hours of treatment with Nattokinase (62.5-2000 FU), the lysis rate of MSLN CAR-T cells against HCC1806 cells significantly increased at all tested E/T ratios. Similarly, when treated with Nattokinase (125-2000 FU), the lysis rate of MSLN CAR-T cells against OVCAR3 cells also showed a significant increasing trend under different E/T ratio conditions [4]. |
| In vivo | Methods: Nattokinase (150, 250 mg/kg; twice daily; for 2 days) was administered orally to rat thrombosis models to investigate the antithrombotic effects of Nattokinase in vivo. Results: The plasma FDPs and D-dimer levels in both the low-dose Nattokinase group and the high-dose Nattokinase group were significantly higher than those in the negative control group. No significant difference was observed in FDPs and D-dimer levels between the high-dose Nattokinase group and the Vermis kinase positive control group. Parazacco spilurus subsp. spilurus.[3] |
| Synonyms | Nattokinase (Natto fermentation) |
| Cas No. | 133876-92-3 |
| Relative Density. | no data available |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O: 80 mg/mL, Sonication is recommended. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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