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AGN 196996

Name: AGN 196996
Brand: TargetMol
SKU: T10261
Price: 54 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10261Cas No. 958295-17-5

AGN 196996 is a potent and selective inhibitor of RARα (Ki: 2 nM), exhibiting very low affinity for RARβ (Ki: 1087 nM) and RARγ (Ki: 8523 nM).

AGN 196996

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Purity: 99.94%

Catalog No. T10261Cas No. 958295-17-5

AGN 196996 is a potent and selective inhibitor of RARα (Ki: 2 nM), exhibiting very low affinity for RARβ (Ki: 1087 nM) and RARγ (Ki: 8523 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$54	-	In Stock
5 mg	$133	-	In Stock
10 mg	$200	-	In Stock
25 mg	$346	-	In Stock
50 mg	$503	-	In Stock
100 mg	$738	-	In Stock
1 mL x 10 mM (in DMSO)	$141	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.94%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	AGN 196996 is a potent and selective inhibitor of RARα (Ki: 2 nM), exhibiting very low affinity for RARβ (Ki: 1087 nM) and RARγ (Ki: 8523 nM).
Targets&IC50	RARγ:8523 nM(Ki), RARβ:1087 nM(Ki), RARα:2 nM(Ki)
In vitro	AGN 196996 is a potent and selective RARα antagonist with a Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM). RARα antagonist AGN 196996 shows no activity in transactivation assays but instead blocks the gene transcriptional activity induced by ATRA and other RAR agonists.[1]

Chemical Properties

Molecular Weight	482.32
Formula	C₂₄H₂₀BrNO₅
Cas No.	958295-17-5
Smiles	CCOc1c(Br)cc(cc1C(=O)c1ccc(C)cc1)C(=O)Nc1ccc(cc1)C(O)=O
Relative Density.	1.453±0.06 g/cm3 (20 °C, 760 mmHg)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 225 mg/mL (466.5 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (6.84 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0733 mL	10.3666 mL	20.7331 mL	103.6656 mL
5 mM	0.4147 mL	2.0733 mL	4.1466 mL	20.7331 mL
10 mM	0.2073 mL	1.0367 mL	2.0733 mL	10.3666 mL
20 mM	0.1037 mL	0.5183 mL	1.0367 mL	5.1833 mL
50 mM	0.0415 mL	0.2073 mL	0.4147 mL	2.0733 mL
100 mM	0.0207 mL	0.1037 mL	0.2073 mL	1.0367 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc