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AGN 196996

Name: AGN 196996
Brand: TargetMol
SKU: T10261
Price: 54 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10261Cas No. 958295-17-5

AGN 196996 is a potent and selective inhibitor of RARα (Ki: 2 nM), exhibiting very low affinity for RARβ (Ki: 1087 nM) and RARγ (Ki: 8523 nM).

AGN 196996

🥰Excellent

Purity: 98.74%

Catalog No. T10261Cas No. 958295-17-5

AGN 196996 is a potent and selective inhibitor of RARα (Ki: 2 nM), exhibiting very low affinity for RARβ (Ki: 1087 nM) and RARγ (Ki: 8523 nM).

Pack Size	Price	Availability
1 mg	$54	In Stock
5 mg	$133	In Stock
10 mg	$200	In Stock
25 mg	$346	In Stock
50 mg	$503	In Stock
100 mg	$738	In Stock
1 mL x 10 mM (in DMSO)	$141	In Stock

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Purity:98.74%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	AGN 196996 is a potent and selective inhibitor of RARα (Ki: 2 nM), exhibiting very low affinity for RARβ (Ki: 1087 nM) and RARγ (Ki: 8523 nM).
Targets&IC50	RARγ:8523 nM(Ki), RARα:2 nM(Ki), RARβ:1087 nM(Ki)
In vitro	AGN 196996 is a potent and selective RARα antagonist with a Ki value of 2 nM; little binding affinity for RARβ(Ki=1087 nM) and RARγ(Ki=8523 nM). RARα antagonist AGN 196996 shows no activity in transactivation assays but instead blocks the gene transcriptional activity induced by ATRA and other RAR agonists.[1]

Chemical Properties

Molecular Weight	482.32
Formula	C₂₄H₂₀BrNO₅
Cas No.	958295-17-5
Smiles	CCOc1c(Br)cc(cc1C(=O)c1ccc(C)cc1)C(=O)Nc1ccc(cc1)C(O)=O
Relative Density.	1.453±0.06 g/cm3 (20 °C, 760 mmHg)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 225.0 mg/mL (466.5 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0733 mL	10.3666 mL	20.7331 mL	103.6656 mL
5 mM	0.4147 mL	2.0733 mL	4.1466 mL	20.7331 mL
10 mM	0.2073 mL	1.0367 mL	2.0733 mL	10.3666 mL
20 mM	0.1037 mL	0.5183 mL	1.0367 mL	5.1833 mL
50 mM	0.0415 mL	0.2073 mL	0.4147 mL	2.0733 mL
100 mM	0.0207 mL	0.1037 mL	0.2073 mL	1.0367 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc