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Zilucoplan TFA

Catalog No. T80083

Synonyms: RA101495 TFA

Zilucoplan TFA (RA101495), a 15-amino acid macrocyclic peptide, serves as a potent inhibitor of complement component 5 (C5). It has applications in the study of immune-mediated necrotising myopathy (IMNM) [1] [2].

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Zilucoplan TFA, CAS N/A

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Biological Description

Chemical Properties

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Description	Zilucoplan TFA (RA101495), a 15-amino acid macrocyclic peptide, serves as a potent inhibitor of complement component 5 (C5). It has applications in the study of immune-mediated necrotising myopathy (IMNM) [1] [2].
In vitro	Zilucoplan (RA101495; 1-1000 nM; 30 min) suppresses the lipopolysaccharide-induced increase in C5a plasma levels in human whole blood, with an inhibitory concentration (IC50) of 474.5 pM. A 65.7% reduction in C5a plasma levels is achieved with a 1 nM concentration of Zilucoplan [2]. This compound binds to the complement component 5 (C5) and prevents the formation of the membrane attack complex (MAC; C5b-9) by inhibiting the cleavage of C5 into C5a and C5b and by binding to C5b, thereby hindering its interaction with C6. This action obstructs the assembly of MAC and the subsequent cell lysis [1].
In vivo	Zilucoplan (RA101495; 10 mg/kg; S.C.; daily for 6 days) effectively inhibits the onset of immune-mediated necrotising myopathy (IMNM) in C5-deficient mice treated with human complement and also offers protective benefits against myopathy in C57BL/6 mice [1].

Synonyms	RA101495 TFA
Molecular Weight	3562.18 (free base)
Formula	(C2H4O)nC126H186N24O32.C2HF3O2

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Zilucoplan TFA Immunology/Inflammation Complement System RA101495 TFA inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.