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Crotedumab
(Synonyms: REGN1193, REGN 1193, Anti-GCGR Reference Antibody) Copy Product Info
🥰Excellent
Synonyms: REGN1193, REGN 1193, Anti-GCGR Reference Antibody
Catalog No. T76862 Copy Product Info
🥰Excellent
Crotedumab (REGN1193) is a humanized antibody targeting GCGR, which reduces fasting blood glucose and improves glucose tolerance, used in diabetes research.
Cas No. 1452387-69-7
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $197 | In Stock | In Stock | |
| 5 mg | $516 | In Stock | In Stock | |
| 10 mg | $828 | - | In Stock | |
| 25 mg | $1,230 | - | In Stock | |
| 50 mg | $1,650 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:96.61% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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Chemical Properties
Antibody Information
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| Description | Crotedumab (REGN1193) is a humanized antibody targeting GCGR, which reduces fasting blood glucose and improves glucose tolerance, used in diabetes research. |
| Targets & IC50 | GCGR:0.1 nM (Kd) |
| In vitro | Crotedumab inhibits glucagon-induced signaling in transfected human, monkey, mouse, and rat HEK293 cells via GCGR with IC50 values of 0.65, 3.2, 0.94, and 1.0 nM, respectively.[1] |
| In vivo | Administration of Crotedumab (a single subcutaneous injection) to diabetic OB/OB and diet-induced obese mice reduced blood sugar to levels observed in GCGR deficient mice. In diet-induced obese mice, Crotedumab reduced food intake, adipose tissue mass, and body weight. A single administration of Crotedumab in diabetic cynomophagus monkeys normalized fasting blood sugar and glucose tolerance, and increased circulating levels of glucagon and amino acids. [1] |
| Synonyms | REGN1193, REGN 1193, Anti-GCGR Reference Antibody |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | GCGR/GLR |
| Molecular Weight | 146.82 kDa |
| Cas No. | 1452387-69-7 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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Related Tags: Crotedumab chemical structure | Crotedumab in vivo | Crotedumab in vitro | Crotedumab molecular weight
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