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Crotedumab
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Catalog No. T76862Cas No. 1452387-69-7
Alias REGN1193, REGN 1193, Anti-GCGR Reference Antibody
Crotedumab (REGN1193) is a humanized antibody targeting GCGR, which reduces fasting blood glucose and improves glucose tolerance, used in diabetes research.
Crotedumab
Crotedumab
😃Good
Catalog No. T76862Alias REGN1193, REGN 1193, Anti-GCGR Reference AntibodyCas No. 1452387-69-7
Crotedumab (REGN1193) is a humanized antibody targeting GCGR, which reduces fasting blood glucose and improves glucose tolerance, used in diabetes research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $197 | In Stock | In Stock | |
| 5 mg | $516 | In Stock | In Stock | |
| 10 mg | $828 | - | In Stock | |
| 25 mg | $1,230 | - | In Stock | |
| 50 mg | $1,650 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:96.61% (SEC-HPLC)
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| Description | Crotedumab (REGN1193) is a humanized antibody targeting GCGR, which reduces fasting blood glucose and improves glucose tolerance, used in diabetes research. |
| Targets&IC50 | GCGR:0.1 nM (Kd) |
| In vitro | Crotedumab inhibits glucagon-induced signaling in transfected human, monkey, mouse, and rat HEK293 cells via GCGR with IC50 values of 0.65, 3.2, 0.94, and 1.0 nM, respectively.[1] |
| In vivo | Administration of Crotedumab (a single subcutaneous injection) to diabetic OB/OB and diet-induced obese mice reduced blood sugar to levels observed in GCGR deficient mice. In diet-induced obese mice, Crotedumab reduced food intake, adipose tissue mass, and body weight. A single administration of Crotedumab in diabetic cynomophagus monkeys normalized fasting blood sugar and glucose tolerance, and increased circulating levels of glucagon and amino acids. [1] |
| Synonyms | REGN1193, REGN 1193, Anti-GCGR Reference Antibody |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | GCGR/GLR |
| Molecular Weight | 146.82 kDa |
| Cas No. | 1452387-69-7 |
| Color | Transparent |
| Appearance | Liquid |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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