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OB 24 hydrochloride

Name: OB 24 hydrochloride
Brand: TargetMol
SKU: T41175
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T41175Cas No. 939825-12-4

OB 24 hydrochloride is a selective, orally active HO-1 inhibitor (IC50=1.9 μM) exhibiting antitumor and anti-metastatic properties, suitable for studying prostate cancer, melanoma, ovarian cancer, and lung cancer metastasis.

OB 24 hydrochloride

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Purity: 99.98%

Catalog No. T41175Cas No. 939825-12-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$47	-	In Stock
5 mg	$110	-	In Stock
10 mg	$176	-	In Stock
25 mg	$388	-	In Stock
50 mg	$662	-	In Stock
100 mg	$1,120	-	In Stock
1 mL x 10 mM (in DMSO)	$121	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.98%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	OB 24 hydrochloride is a selective, orally active HO-1 inhibitor (IC50=1.9 μM) exhibiting antitumor and anti-metastatic properties, suitable for studying prostate cancer, melanoma, ovarian cancer, and lung cancer metastasis.
In vitro	OB 24 hydrochloride (10 μM, 24–48 h) inhibited approximately 20% growth and 62% HO-1 expression in PC3M cells. OB 24 hydrochloride (10 μM, 96 h) suppressed intracellular ROS by 25% [1]. OB 24 hydrochloride (6.5 μM) reduced cell proliferation by approximately 10%, HO-1 activity by 59%, and intracellular ROS by 43% in HO-1-overexpressing rat glioma C6 cells [1]. OB 24 hydrochloride (5-10 μM, 10 min) reduced MAPK ERK and p38 kinase activity, producing similar inhibition in LNCaP and DU145 cells [1].
In vivo	OB 24 hydrochloride (10–60 mg/kg; intraperitoneal injection; days 1, 3, and 5 of each cycle for 4 cycles) dose-dependently inhibited tumor growth in PC3M Scid male mice without causing weight loss [1]. OB 24 hydrochloride (30 mg/kg; intravenous injection; days 1, 3, and 5 of each cycle, for 4 cycles) reduced tumor growth by approximately 50% and inhibited lymph node and lung metastasis in PC3M Scid male mice with palpable advanced prostate cancer [1].

Chemical Properties

Molecular Weight	373.68
Formula	C₁₅H₁₈BrClN₂O₂
Cas No.	939825-12-4
Smiles	Cl.BrC1=CC=C(C=C1)CCC2(OCCO2)CN3C=NC=C3
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (214.09 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6761 mL	13.3804 mL	26.7609 mL	133.8043 mL
5 mM	0.5352 mL	2.6761 mL	5.3522 mL	26.7609 mL
10 mM	0.2676 mL	1.3380 mL	2.6761 mL	13.3804 mL
20 mM	0.1338 mL	0.6690 mL	1.3380 mL	6.6902 mL
50 mM	0.0535 mL	0.2676 mL	0.5352 mL	2.6761 mL
100 mM	0.0268 mL	0.1338 mL	0.2676 mL	1.3380 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc